PMID- 21353258
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20221207
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 60
IP  - 8
DP  - 2011 Aug
TI  - Bioactive androgens and glucuronidated androgen metabolites are associated with 
      subcutaneous and ectopic skeletal muscle adiposity among older black men.
PG  - 1178-85
LID - 10.1016/j.metabol.2010.12.014 [doi]
AB  - Aging is associated with declining serum levels of androgenic hormones and with 
      increased skeletal muscle fat infiltration, an emerging risk factor for type 2 
      diabetes mellitus (T2DM). Androgens regulate fat mass and glucose homeostasis, 
      but the effect of androgenic hormones on skeletal muscle fat infiltration is 
      largely unknown. Thus, the aim of the current study was to examine the 
      association of serum androgens and their precursors and metabolites with skeletal 
      muscle fat infiltration and T2DM in a black male population group at high risk of 
      T2DM. Serum androgens, estrogens, and androgen precursors and metabolites were 
      measured using mass spectrometry; and calf skeletal muscle fat distribution 
      (subcutaneous and intermuscular fat; skeletal muscle density) was measured using 
      quantitative computed tomography in 472 Afro-Caribbean men 65 years and older. 
      Bioactive androgens, testosterone, free testosterone, and dihydrotestosterone 
      were associated with less skeletal muscle fat infiltration (r = -0.14 to -0.18, P 
      < .05) and increased skeletal muscle density (r = 0.10 to 0.14, P < .05), 
      independent of total adiposity. In addition, glucuronidated androgen metabolites 
      were associated with less subcutaneous fat (r = -0.11 to -0.15, P < .05). 
      Multivariate logistic regression analysis identified an increased level of 
      3alpha-diol-3 glucuronide (odds ratio = 1.38, P < .01) and a decreased level of 
      dihydrotestosterone (odds ratio = 0.66, P < .01) to be significantly associated 
      with T2DM. Our findings suggest that, in elderly black men, independent of total 
      adiposity, bioactive androgens and glucuronidated androgen metabolites may play 
      previously unrecognized role in skeletal muscle fat distribution. Longitudinal 
      studies are needed to further evaluate the relationship between androgens and 
      androgen metabolites with changes in skeletal muscle fat distribution with aging 
      and the incidence of T2DM.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Miljkovic, Iva
AU  - Miljkovic I
AD  - Department of Epidemiology, Graduate School of Public Health, University of 
      Pittsburgh, Pittsburgh, PA, USA. miljkovici@edc.pitt.edu
FAU - Cauley, Jane A
AU  - Cauley JA
FAU - Dressen, Amy S
AU  - Dressen AS
FAU - Gordon, Christopher L
AU  - Gordon CL
FAU - Goodpaster, Bret H
AU  - Goodpaster BH
FAU - Kuller, Lewis H
AU  - Kuller LH
FAU - Bunker, Clareann H
AU  - Bunker CH
FAU - Patrick, Alan L
AU  - Patrick AL
FAU - Wheeler, Victor W
AU  - Wheeler VW
FAU - Orwoll, Eric S
AU  - Orwoll ES
FAU - Zmuda, Joseph M
AU  - Zmuda JM
LA  - eng
GR  - P30 AG024827/AG/NIA NIH HHS/United States
GR  - R01AR049747/AR/NIAMS NIH HHS/United States
GR  - K01DK083029/DK/NIDDK NIH HHS/United States
GR  - K01 DK083029/DK/NIDDK NIH HHS/United States
GR  - R01 AR049747-01A1/AR/NIAMS NIH HHS/United States
GR  - R01 AR049747/AR/NIAMS NIH HHS/United States
GR  - K01 DK083029-02/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110225
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Androgens)
SB  - IM
MH  - Adiposity/*physiology
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*metabolism
MH  - Androgens/*metabolism
MH  - Black People
MH  - Body Composition/physiology
MH  - Body Mass Index
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Male
MH  - Muscle, Skeletal/*metabolism
MH  - Overweight/metabolism
MH  - Trinidad and Tobago
PMC - PMC3106138
MID - NIHMS263916
COIS- Conflict of interest: CL Gordon has received a consulting fee for reading of the 
      pQCT scans. Other authors have nothing to disclose.
EDAT- 2011/03/01 06:00
MHDA- 2011/09/29 06:00
PMCR- 2012/08/01
CRDT- 2011/03/01 06:00
PHST- 2010/09/27 00:00 [received]
PHST- 2010/12/15 00:00 [revised]
PHST- 2010/12/27 00:00 [accepted]
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - S0026-0495(11)00002-3 [pii]
AID - 10.1016/j.metabol.2010.12.014 [doi]
PST - ppublish
SO  - Metabolism. 2011 Aug;60(8):1178-85. doi: 10.1016/j.metabol.2010.12.014. Epub 2011 
      Feb 25.