PMID- 21353618
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20220408
IS  - 1778-7254 (Electronic)
IS  - 1297-319X (Linking)
VI  - 78
IP  - 6
DP  - 2011 Dec
TI  - Multi-needle aponeurotomy for advanced Dupuytren's disease: preliminary results 
      of safety and efficacy (MNA 1 study).
PG  - 625-8
LID - 10.1016/j.jbspin.2011.01.008 [doi]
AB  - AIM: To assess the safety and efficacy of multi-needle aponeurotomy (MNA) for 
      advanced Duputren's disease. METHODS: This prospective study included patients 
      with age more than 17 years, Dupuytren's contracture with palmo-digital or 
      poly-digital involvement, presumed NA number needed to treat>4, and availability 
      for at least 1-month follow-up after MNA. Outcome measures were Tubiana score and 
      passive extension deficit, after MNA and at 1 and 6 months; self-assessed 
      disability and satisfaction at 1 and 6 months; and adverse events (AEs). RESULTS: 
      Thirty patients were included. MNA was performed on 37 hands and 99 rays. Among 
      25 assessed MNA sessions for treatment-related discomfort, patients considered 22 
      (88%) not at all to moderately painful. Six minor AEs, representing 2 for every 
      100 NAs, were reported. Tubiana scores at baseline (5.3+/-2.3, n=35) were improved 
      after treatment (1.7+/-1.8, n=32, P<0.0001), at 1 month (2.2+/-1.4, n=26, P<0.0001) 
      and at 6 months (2.8+/-2.7, n=19, P<0.01). Passive extension deficit was greatly 
      reduced after treatment and persisted at follow-up. Disability scores at baseline 
      (27.6+/-26.9, n=37) were reduced at 1 month (13.2+/-19.5, n=26, P=0.02) and at 6 
      months (5.2+/-11.6, n=20, P<0.001). Patients were highly satisfied at 1 month 
      (100%, n=25) and 6 months (95%, n=19). CONCLUSION: MNA appears safe and effective 
      for advanced Dupuytren's disease. It could become a treatment of reference and 
      contribute to reducing the need for surgery in this indication.
CI  - Copyright (c) 2011 Societe francaise de rhumatologie. All rights reserved.
FAU - Beaudreuil, Johann
AU  - Beaudreuil J
AD  - Unite rhumatologique des affections de la main, service de rhumatologie, 
      Universite Paris-7, Paris, France. johann.beaudreuil@lrb.aphp.fr
FAU - Lermusiaux, Jean-Luc
AU  - Lermusiaux JL
FAU - Teyssedou, Jean-Pierre
AU  - Teyssedou JP
FAU - Lahalle, Sophie
AU  - Lahalle S
FAU - Lasbleiz, Sandra
AU  - Lasbleiz S
FAU - Bernabe, Brigitte
AU  - Bernabe B
FAU - Lellouche, Henri
AU  - Lellouche H
FAU - Orcel, Philippe
AU  - Orcel P
FAU - Bardin, Thomas
AU  - Bardin T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20110225
PL  - France
TA  - Joint Bone Spine
JT  - Joint bone spine
JID - 100938016
SB  - IM
MH  - Aged
MH  - Disability Evaluation
MH  - Dupuytren Contracture/physiopathology/*therapy
MH  - Fascia/*physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Needles
MH  - Orthopedic Procedures/adverse effects/*instrumentation/*methods
MH  - Outcome Assessment, Health Care
MH  - Patient Satisfaction
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Self Report
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2011/03/01 06:00
MHDA- 2012/07/03 06:00
CRDT- 2011/03/01 06:00
PHST- 2010/09/16 00:00 [received]
PHST- 2011/01/05 00:00 [accepted]
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
AID - S1297-319X(11)00009-1 [pii]
AID - 10.1016/j.jbspin.2011.01.008 [doi]
PST - ppublish
SO  - Joint Bone Spine. 2011 Dec;78(6):625-8. doi: 10.1016/j.jbspin.2011.01.008. Epub 
      2011 Feb 25.