PMID- 21354454
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20111117
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 6
DP  - 2011 Jun
TI  - Association of HLA-G alleles and 3' UTR 14 bp haplotypes with recurrent 
      miscarriage in Brazilian couples.
PG  - 479-85
LID - 10.1016/j.humimm.2011.02.011 [doi]
AB  - Human leukocyte antigen (HLA)-G expression is restricted, expressed on 
      trophoblast, with a major role in fetus acceptance. In addition to the 46 HLA-G 
      alleles, the presence or absence of a 14 bp polymorphism located in the 3' UTR 
      contributes to gene polymorphism that may influence both HLA-G mRNA stability and 
      HLA-G isoform's splicing and consequently could play an immunomodulatory function 
      in pregnancy. To elucidate the role of HLA-G polymorphism in pregnancy, HLA-G 
      allele frequencies and the 14 bp polymorphisms were analyzed and compared in 60 
      couples with recurrent miscarriage (RM) and 68 fertile control couples. Two 
      haplotypes showed a significant elevated frequency in patients 
      (HLA-G*01:01:08/+14, p(c) < 0.0001 and HLA-G*01:04:01/-14, p(c) < 0.0001). The 
      haplotype HLA-G*01:01:A/+14 exhibited a significant protective effect against RM 
      in women (p(c) = 0.0238). Remarkably, significant differences in linkage 
      disequilibrium were observed between patient and control groups. Two alleles 
      showed a positive association with the +14 bp segment in RM patients and a strong 
      negative association with fertile controls (HLA-G*01:01:08 = patients D' = 
      0.295-0.371; controls D' = -0.715 to -1.000; HLAG* 01:05N = patients D' = 
      0.728-1.000; controls D' = -1.000). HLA-G*01:04:01 showed a negative association 
      with the 14 bp segment in patients and a positive association in controls 
      (patients D' = -0.249 to - 0.674; controlss D' = 0.688-1.000). Our results 
      suggest that haplotypic combinations of HLA-G alleles and the 14 bp segment may 
      be associated with RM.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Vargas, Rafael Gustavo
AU  - Vargas RG
AD  - Immunogenetics and Histocompatibility Laboratory, Genetics Department, 
      Universidade Federal do Parana, Curitiba, Brazil.
FAU - Sarturi, Paulo Roberto
AU  - Sarturi PR
FAU - Mattar, Sibelle Botogosque
AU  - Mattar SB
FAU - Bompeixe, Eni Piccioni
AU  - Bompeixe EP
FAU - Silva, Joandrei dos Santos
AU  - Silva Jdos S
FAU - Pirri, Alessandro
AU  - Pirri A
FAU - Bicalho, Maria da Graca
AU  - Bicalho Mda G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110225
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (3' Untranslated Regions)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - 3' Untranslated Regions/*genetics
MH  - Abortion, Habitual/epidemiology/*genetics/physiopathology
MH  - Adult
MH  - Brazil
MH  - DNA Mutational Analysis
MH  - Family Characteristics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Haplotypes/genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Polymorphism, Genetic
MH  - Pregnancy
EDAT- 2011/03/01 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/03/01 06:00
PHST- 2010/07/13 00:00 [received]
PHST- 2011/02/14 00:00 [revised]
PHST- 2011/02/22 00:00 [accepted]
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S0198-8859(11)00039-5 [pii]
AID - 10.1016/j.humimm.2011.02.011 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Jun;72(6):479-85. doi: 10.1016/j.humimm.2011.02.011. Epub 2011 
      Feb 25.