PMID- 21354458
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20141120
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 5
DP  - 2011 May
TI  - The association of HLA-DRB1 alleles with antineutrophil cytoplasmic 
      antibody-associated systemic vasculitis in Chinese patients.
PG  - 422-5
LID - 10.1016/j.humimm.2011.02.017 [doi]
AB  - Antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (AASV) 
      is a group of autoimmune diseases. The human leukocyte antigen (HLA) system is 
      devoted to the pathogenesis of these autoimmune diseases. The present study aimed 
      to investigate the distribution of HLA-DRB1 alleles in Chinese AASV patients and 
      its potential association with clinical and pathologic characteristics. This 
      study included 152 Chinese patients with AASV and 200 healthy controls. Typing of 
      HLA-DRB1 alleles was performed by bidirectional sequencing of exon 2. Compared 
      with normal controls, DRB1*1454 was significantly less prevalent in AASV patients 
      (0/304 vs 14/400, p = 4.6 x 10(-4), p corrected (p(c)) = 0.017), whereas 
      DRB1*1101 was significantly more frequent in patients with MPA (32/214 vs 26/400, 
      p = 6.4 x 10(-4), p(c) = 0.023). In patients with Wegener's granulomatosis (WG) 
      who were PR3-ANCA positive, DRB1*1202 (8/38 vs 20/400, p = 1.3 x 10(-3), p(c) = 
      0.047) was more prevalent than in normal controls. Compared with normal controls, 
      HLA-DRB1*1454 was less prevalent in AASV patients, whereas DRB1*1101 was 
      significantly more frequent in patients with microscopic polyangiitis. 
      HLA-DRB1*1202 was prevalent among patients with PR3-ANCA-positive WG.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Luo, Huan
AU  - Luo H
AD  - Renal Division, Department of Medicine, Peking University First Hospital, 
      Beijing, China.
FAU - Chen, Min
AU  - Chen M
FAU - Yang, Rui
AU  - Yang R
FAU - Xu, Peng-Cheng
AU  - Xu PC
FAU - Zhao, Ming-Hui
AU  - Zhao MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110225
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*12:02 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Antibodies, Antineutrophil Cytoplasmic/blood
MH  - China
MH  - Female
MH  - Genetic Association Studies
MH  - Granulomatosis with Polyangiitis/blood/*genetics/*immunology/physiopathology
MH  - HLA-DR Antigens/genetics/*metabolism
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Systemic Vasculitis/blood/*genetics/*immunology/physiopathology
EDAT- 2011/03/01 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/01 06:00
PHST- 2010/12/26 00:00 [received]
PHST- 2011/01/28 00:00 [revised]
PHST- 2011/02/22 00:00 [accepted]
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S0198-8859(11)00045-0 [pii]
AID - 10.1016/j.humimm.2011.02.017 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 May;72(5):422-5. doi: 10.1016/j.humimm.2011.02.017. Epub 2011 
      Feb 25.