PMID- 21355720
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20221207
IS  - 1557-8593 (Electronic)
IS  - 1520-9156 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Apr
TI  - Recovery of beta-cell functions with low-dose insulin therapy: study in newly 
      diagnosed type 2 diabetes mellitus patients.
PG  - 461-5
LID - 10.1089/dia.2010.0187 [doi]
AB  - AIM: Insulin therapy induces remission in subjects with newly diagnosed type 2 
      diabetes mellitus (T2DM). This study assessed the insulin and C-peptide levels in 
      newly diagnosed T2DM subjects during low-dose insulin therapy. SUBJECTS AND 
      METHODS: Twenty newly diagnosed, drug-naive, T2DM patients without acute or 
      chronic complications were the subjects for this study. Premixed insulin (70/30), 
      16 units, as two divided doses, was started for all subjects after preliminary 
      investigations. The same dose of insulin was continued until normoglycemia was 
      achieved. Subsequently the insulin dose was down-titrated. Plasma insulin, 
      C-peptide, and blood glucose (both fasting and after breakfast) were measured at 
      baseline and monthly for 6 months. Body weight and glycosylated hemoglobin 
      (HbA1c) were measured every 3 months and the lipid profile was obtained at 
      baseline and at 6 months. RESULTS: Blood glucose levels showed a rapid decreasing 
      trend and reached the near-normoglycemic range by 3 months, whereas plasma 
      insulin and C-peptide showed a slow and steady increase until the fourth month 
      and remained the same during the next 2 months of follow-up. HbA1c was 11.3 +/- 
      1.4% (range, 8.6-13.5%) and 7.05 +/- 0.54% (range, 6.3-8.1%) at the time of 
      diagnosis and at the end of 6 months, respectively. The mean weights of the study 
      subjects at baseline and 3 and 6 months were 70 +/- 16 kg (range, 44-95 kg), 68 +/- 
      13 kg, and 68 +/- 13 kg (P = 0.083), respectively. Total cholesterol, low-density 
      lipoprotein-cholesterol, and triglycerides decreased, whereas high-density 
      lipoprotein-cholesterol was higher at 6 months. CONCLUSION: Low-dose insulin 
      therapy in newly diagnosed T2DM leads to beta-cell recovery (as documented by plasma 
      insulin and C-peptide levels) by 3-4 months.
FAU - Bhattacharya, Saptarshi
AU  - Bhattacharya S
AD  - Department of Endocrinology and Metabolism, All India Institute of Medical 
      Sciences, New Dehli, India.
FAU - Ammini, Ariachery C
AU  - Ammini AC
FAU - Jyotsna, Viveka
AU  - Jyotsna V
FAU - Gupta, Nandita
AU  - Gupta N
FAU - Dwivedi, Sadanand
AU  - Dwivedi S
LA  - eng
PT  - Journal Article
DEP - 20110228
PL  - United States
TA  - Diabetes Technol Ther
JT  - Diabetes technology & therapeutics
JID - 100889084
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects/physiology
MH  - C-Peptide/blood
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism/*pathology
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage/blood
MH  - Insulin/*administration & dosage/blood
MH  - Insulin-Secreting Cells/*drug effects/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Statistics, Nonparametric
MH  - Triglycerides/blood
EDAT- 2011/03/02 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1089/dia.2010.0187 [doi]
PST - ppublish
SO  - Diabetes Technol Ther. 2011 Apr;13(4):461-5. doi: 10.1089/dia.2010.0187. Epub 
      2011 Feb 28.