PMID- 21355951
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20110301
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 61
IP  - 3
DP  - 2011 Mar
TI  - Retinoid X receptor gamma up-regulation is correlated with dedifferentiation of tumor 
      cells and lymph node metastasis in papillary thyroid carcinoma.
PG  - 109-15
LID - 10.1111/j.1440-1827.2010.02623.x [doi]
AB  - The expression of retinoid X receptor gamma (RXRgamma) and the clinicopathological 
      parameters of total 69 patients with papillary thyroid carcinoma (PTC) larger 
      than 1 cm were examined. The PTCs were classified into two groups according to 
      the presence of loss of cellular polarity/cohesiveness (LOP/C). The expression of 
      RXRgamma mRNA was examined by reverse transcriptase polymerase chain reaction and 
      quantitative real-time PCR. The RXRgamma mRNA up-regulation was found to be 
      positively correlated with extrathyroid invasion (r = 0.293, P = 0.019), advanced 
      tumor stage (r = 0.318, P = 0.016) and lymph node metastasis (LNM) (r = 0.338, P 
      = 0.005), as well as LOP/C (r = 0.345, P = 0.004), which was proposed as a 
      histological characteristic of poor cellular differentiation. The RXRgamma mRNA 
      expression, as well as extrathyroid invasion, LOP/C and advanced tumor stage, was 
      further confirmed to be one of the independent predictive factors (Odds ratio: 
      6.545; 95% confidence interval: 1.575-27.208) of LNM using multivariate analysis. 
      These results suggest that RXRgamma may play a role in the dedifferentiation and 
      metastasis of PTC.
CI  - (c) 2010 The Authors. Pathology International (c) 2010 Japanese Society of Pathology 
      and Blackwell Publishing Asia Pty Ltd.
FAU - Liu, Zhiyan
AU  - Liu Z
AD  - Department of Pathology and Pathophysiology, Shandong University School of 
      Medicine, Jinan, Shandong, China.
FAU - Zhou, Gengyin
AU  - Zhou G
FAU - Nakamura, Misa
AU  - Nakamura M
FAU - Bai, Yanhua
AU  - Bai Y
FAU - Li, Yaqiong
AU  - Li Y
FAU - Ozaki, Takashi
AU  - Ozaki T
FAU - Mori, Ichiro
AU  - Mori I
FAU - Miyauchi, Akira
AU  - Miyauchi A
FAU - Kakudo, Kennichi
AU  - Kakudo K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101208
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (RNA, Messenger)
RN  - 0 (Retinoid X Receptor gamma)
SB  - IM
MH  - Adenocarcinoma, Papillary/genetics/metabolism/*secondary
MH  - Cell Dedifferentiation/genetics
MH  - Cell Transformation, Neoplastic
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lymph Nodes/metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - RNA, Messenger/metabolism
MH  - Retinoid X Receptor gamma/*genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Thyroid Neoplasms/genetics/metabolism/*pathology
MH  - Thyroidectomy
MH  - Up-Regulation/genetics
EDAT- 2011/03/02 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.1111/j.1440-1827.2010.02623.x [doi]
PST - ppublish
SO  - Pathol Int. 2011 Mar;61(3):109-15. doi: 10.1111/j.1440-1827.2010.02623.x. Epub 
      2010 Dec 8.