PMID- 21356182
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20131121
IS  - 1879-1514 (Electronic)
IS  - 0166-445X (Linking)
VI  - 102
IP  - 3-4
DP  - 2011 Apr
TI  - Natural mixtures of POPs affected body weight gain and induced transcription of 
      genes involved in weight regulation and insulin signaling.
PG  - 197-204
LID - 10.1016/j.aquatox.2011.01.017 [doi]
AB  - Obesity is reaching epidemic proportions worldwide, and is associated with 
      chronic illnesses such as diabetes, cardiovascular disease, hypertension and 
      dyslipidemias (metabolic syndrome). Commonly held causes of obesity are 
      overeating coupled with a sedentary lifestyle. However, it has also been 
      postulated that exposure to endocrine disrupting chemicals (EDCs) may be related 
      to the significant increase in the prevalence of obesity and associated diseases. 
      In the present study, developmental and reproductive effects of lifelong exposure 
      to environmentally relevant concentrations of two natural mixtures of persistent 
      organic pollutants (POPs) were investigated using classical and molecular methods 
      in a controlled zebrafish model. The mixtures used were extracted from burbot 
      (Lota lota) liver originating from freshwater systems in Norway (Lake Mjosa and 
      Lake Losna). The concentration of POPs in the zebrafish ranged from levels 
      detected in wild fish (Lake Mjosa and Lake Losna), to concentrations reported in 
      human and wildlife populations. Phenotypic effects observed in both exposure 
      groups included (1) earlier onset of puberty, (2) elevated male/female sex ratio, 
      and (3) increased body weight at 5 months of age. Interestingly, genome-wide 
      transcription profiling identified functional networks of genes, in which key 
      regulators of weight homeostasis (PPARs, glucocoricoids, CEBPs, estradiol), 
      steroid hormone functions (glucocoricoids, estradiol, NCOA3) and insulin 
      signaling (HNF4A, CEBPs, PPARG) occupied central positions. The increased weight 
      and the regulation of genes associated with weight homeostasis and insulin 
      signaling observed in the present study suggest that environmental pollution may 
      affect the endocrine regulation of the metabolism, possibly leading to increased 
      weight gain and obesity.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Lyche, Jan L
AU  - Lyche JL
AD  - Dept. Production Animal Clinical Science, Norwegian School of Veterinary Science, 
      Oslo, Norway. jan.l.lyche@veths.no
FAU - Nourizadeh-Lillabadi, Rasoul
AU  - Nourizadeh-Lillabadi R
FAU - Karlsson, Camilla
AU  - Karlsson C
FAU - Stavik, Benedicte
AU  - Stavik B
FAU - Berg, Vidar
AU  - Berg V
FAU - Skare, Janneche Utne
AU  - Skare JU
FAU - Alestrom, Peter
AU  - Alestrom P
FAU - Ropstad, Erik
AU  - Ropstad E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110226
PL  - Netherlands
TA  - Aquat Toxicol
JT  - Aquatic toxicology (Amsterdam, Netherlands)
JID - 8500246
RN  - 0 (Glucocorticoids)
RN  - 0 (Insulin)
RN  - 0 (Peroxisome Proliferator-Activated Receptors)
RN  - 0 (Water Pollutants, Chemical)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Estradiol/genetics/metabolism
MH  - Gene Expression/*drug effects
MH  - Glucocorticoids/genetics/metabolism
MH  - Homeostasis/drug effects
MH  - Insulin/*metabolism
MH  - Peroxisome Proliferator-Activated Receptors/genetics/metabolism
MH  - Signal Transduction/*drug effects
MH  - Water Pollutants, Chemical/*toxicity
MH  - Weight Gain/*drug effects
MH  - Zebrafish/genetics/metabolism
EDAT- 2011/03/02 06:00
MHDA- 2011/05/14 06:00
CRDT- 2011/03/02 06:00
PHST- 2010/09/02 00:00 [received]
PHST- 2011/01/26 00:00 [revised]
PHST- 2011/01/29 00:00 [accepted]
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
AID - S0166-445X(11)00024-5 [pii]
AID - 10.1016/j.aquatox.2011.01.017 [doi]
PST - ppublish
SO  - Aquat Toxicol. 2011 Apr;102(3-4):197-204. doi: 10.1016/j.aquatox.2011.01.017. 
      Epub 2011 Feb 26.