PMID- 21356186
OWN - NLM
STAT- MEDLINE
DCOM- 20110427
LR  - 20110301
IS  - 2210-7762 (Print)
VI  - 204
IP  - 1
DP  - 2011 Jan
TI  - The prognostic significance of cytogenetics and molecular profiling in multiple 
      myeloma.
PG  - 3-12
LID - 10.1016/j.cancergencyto.2010.11.002 [doi]
AB  - Multiple myeloma (MM) is a plasma cell malignancy characterized by very complex 
      cytogenetic and molecular genetic aberrations. In newly diagnosed symptomatic 
      patients, the modal chromosome number is usually either hyperdiploid with 
      multiple trisomies or hypodiploid with one of several types of immunoglobulin 
      heavy chain (Ig) translocations. The chromosome ploidy status and Ig 
      rearrangements are two genetic criteria that are used to help stratify patients 
      into prognostic groups based on the findings of conventional cytogenetics and 
      fluorescence in situ hybridization (FISH). In general, the hypodiploid group with 
      t(4;14)(p16;q32) or t(14;16)(q32;q23) is considered a high-risk group, while the 
      hyperdiploid patients with t(11;14)(q13;q32) are considered a better prognostic 
      group. As the disease progresses, it becomes more proliferative and develops a 
      number of secondary chromosome aberrations. These secondary aberrations commonly 
      involve MYC rearrangements, del(13q), del(17p), and the deletion of 1p and/or 
      amplification of 1q. Of the secondary aberrations, del(17p) is consistently 
      associated with poor prognosis. All of these cytogenetic aberrations and many 
      additional ones are now identified by means of high resolution molecular 
      profiling. Gene expression profiling (GEP), array comparative genomic 
      hybridization (aCGH), and single-nucleotide polymorphism (SNP) arrays have been 
      able to identify novel genetic aberration patterns that have previously gone 
      unrecognized. With the integration of data from these profiling techniques, new 
      subclassifications of MM have been proposed which define distinct molecular 
      genetic subgroups. In this review, the findings from conventional cytogenetics, 
      interphase FISH, GEP, aCGH, and SNP profiles are described to provide the 
      conceptual framework for defining the emerging molecular genetic subgroups with 
      prognostic significance.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Sawyer, Jeffrey R
AU  - Sawyer JR
AD  - Department of Pathology and Myeloma Institute for Research and Therapy, 
      University of Arkansas for Medical Sciences, Little Rock, AR, USA. 
      sawyerjeffreyr@uams.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
SB  - IM
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/ultrastructure
MH  - Chromosomes, Human, Pair 13/ultrastructure
MH  - Chromosomes, Human, Pair 17/ultrastructure
MH  - Comparative Genomic Hybridization
MH  - Cytogenetic Analysis/methods
MH  - Cytogenetics
MH  - Gene Expression Profiling
MH  - Humans
MH  - Karyotyping
MH  - Medical Oncology/methods
MH  - Multiple Myeloma/*diagnosis/*genetics/metabolism
MH  - Prognosis
EDAT- 2011/03/02 06:00
MHDA- 2011/04/28 06:00
CRDT- 2011/03/02 06:00
PHST- 2010/11/01 00:00 [received]
PHST- 2010/11/01 00:00 [accepted]
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/04/28 06:00 [medline]
AID - S0165-4608(10)00564-9 [pii]
AID - 10.1016/j.cancergencyto.2010.11.002 [doi]
PST - ppublish
SO  - Cancer Genet. 2011 Jan;204(1):3-12. doi: 10.1016/j.cancergencyto.2010.11.002.