PMID- 21360015
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20220408
IS  - 1437-7799 (Electronic)
IS  - 1342-1751 (Linking)
VI  - 15
IP  - 4
DP  - 2011 Aug
TI  - Altered monocyte-derived dendritic cell function in patients on hemodialysis: a 
      culprit for underlying impaired immune responses.
PG  - 546-53
LID - 10.1007/s10157-011-0424-2 [doi]
AB  - BACKGROUND: Patients with end-stage renal disease (ESRD) are known to have 
      impaired immune function. Dendritic cells (DCs) are the major antigen-presenting 
      cells that initiate primary immune responses, linking innate and adaptive 
      immunity. Although suboptimal immune responses to vaccination, as frequently 
      observed in ESRD patients, might suggest the presence of impaired DC function, 
      the precise nature of altered DC function is not fully understood. METHODS: In 
      the current study, we compared the maturation status, viability, and function of 
      monocyte-derived DCs (moDCs) of patients on hemodialysis (HD) with healthy 
      controls. RESULTS: Surface expression of major histocompatibility complex class 
      II, CD83, and CD86, and chemokine receptor CCR7 in moDCs was not different 
      between HD patients and healthy controls. No significant difference was detected 
      in the viability of moDCs determined by expression of annexin V and propidium 
      iodide between two groups. However, moDCs from HD patients produced significantly 
      higher amounts of IL-6 when stimulated by cytokine cocktails compared to healthy 
      controls. In addition, mature moDCs from HD patients showed significantly 
      enhanced allogeneic T-cell proliferation compared to healthy controls. 
      CONCLUSIONS: Our data demonstrate aberrant DC function in HD patients and suggest 
      that this might contribute to impaired immune responses.
FAU - Choi, Hye Min
AU  - Choi HM
AD  - Division of Nephrology, Department of Internal Medicine, Korea University Medical 
      College, Seoul, Korea.
FAU - Woo, Young Seok
AU  - Woo YS
FAU - Kim, Myung Gyu
AU  - Kim MG
FAU - Jo, Sang-Kyung
AU  - Jo SK
FAU - Cho, Won Yong
AU  - Cho WY
FAU - Kim, Hyoung Kyu
AU  - Kim HK
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - Japan
TA  - Clin Exp Nephrol
JT  - Clinical and experimental nephrology
JID - 9709923
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Cytokines
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Interleukin-6/biosynthesis
MH  - Kidney Failure, Chronic/*immunology/physiopathology/therapy
MH  - Middle Aged
MH  - Monocytes/*immunology
MH  - Renal Dialysis/*adverse effects
MH  - T-Lymphocytes/cytology
EDAT- 2011/03/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/02 06:00
PHST- 2010/10/03 00:00 [received]
PHST- 2011/02/07 00:00 [accepted]
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10157-011-0424-2 [doi]
PST - ppublish
SO  - Clin Exp Nephrol. 2011 Aug;15(4):546-53. doi: 10.1007/s10157-011-0424-2. Epub 
      2011 Mar 1.