PMID- 21361033
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20181201
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 45
IP  - 11
DP  - 2010 Nov
TI  - [Advance in the study of poly(lactide-co-glycolide) nano/microparticles as gene 
      vector].
PG  - 1346-53
AB  - Biodegradable nano/microparticles of poly(D, L-lactide-co-glycolide) (PLGA) is a 
      novel non-viral gene vector, which has many advantages, such as safety, 
      non-immunogenicity, easy of large-scale preparation and well load-capability. 
      Therefore, more and more attentions and researches have been paid on its 
      application. Especially, PLGA has shown enormous potential application value and 
      space in the field of plasmid DNA (pDNA) delivery system. On the basis of the 
      current situation of PLGA nano/microparticles for pDNA delivery, this paper 
      focused on summarizing the current preparation approaches and surface modified 
      methods of PLGA particle, furthermore showing its application in gene therapy and 
      genetic vaccine delivery. These showed that PLGA nano/microparticles have 
      extensive prospect in the development of controlled gene delivery system.
FAU - Zeng, Ping
AU  - Zeng P
AD  - Chemistry and Chemical Engineering College, Chongqing University, Chongqing 
      400030, China.
FAU - Peng, Ming-Li
AU  - Peng ML
FAU - Xu, Yi
AU  - Xu Y
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Drug Carriers)
RN  - 0 (Emulsions)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Drug Carriers/chemistry
MH  - *Drug Delivery Systems
MH  - Emulsions
MH  - *Gene Transfer Techniques
MH  - Genetic Vectors/chemistry
MH  - Lactic Acid/administration & dosage/*chemistry
MH  - Microspheres
MH  - Nanoparticles
MH  - Particle Size
MH  - Plasmids
MH  - Polyglycolic Acid/administration & dosage/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers
EDAT- 2011/03/03 06:00
MHDA- 2012/10/02 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
PST - ppublish
SO  - Yao Xue Xue Bao. 2010 Nov;45(11):1346-53.