PMID- 21362222
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20181201
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Feb
TI  - [Chemotaxis-related factors are expressed abnormally in bone marrow mesenchymal 
      stem cells of multiple myeloma patients].
PG  - 59-63
AB  - This study was aimed to investigate the mRNA expression levels of hepatocyte 
      growth factor (HGF), stromal cell-derived factor-1 (SDF-1), monocyte chemotactic 
      protein-1 (MCP-1) and interleukin-8 (IL-8) in bone marrow mesenchymal stem cells 
      (MSC) from multiple myeloma (MM) patients. The mRNA expression levels of HGF, 
      SDF-1, MCP-1 and IL-8 in bone marrow MSC from 20 newly diagnosed MM patients were 
      detected by real time quantitative RT-PCR and were compared with that in 9 
      controls. The results indicated that the mean mRNA expression level of HGF was 
      up-regulated in MM patients, as compared with controls (p < 0.01). However, the 
      mean mRNA expression level of SDF-1 mRNA was down-regulated in MM patients, as 
      compared with controls (p < 0.05). There was no significant difference in the 
      mRNA expression levels of MCP-1 and IL-8 between MM and control cohorts (p > 
      0.05). It is concluded that BM-MSC from MM patients express HGF, SDF-1, MCP-1, 
      IL-8, but these chemotaxis-related factors expression of bone marrow 
      microenvironment cellular component are dysregulated in MM patients, which may 
      result from the interplay between MM cells and MSC.
FAU - Hu, Hui-Jin
AU  - Hu HJ
AD  - Department of Hematology, Nanjing Medical University, Nanjing 210029, Jiangsu 
      Province, China.
FAU - Lu, Hua
AU  - Lu H
FAU - Fei, Xiao-Ming
AU  - Fei XM
FAU - Li, Jun-Xia
AU  - Li JX
FAU - Li, Jian-Yong
AU  - Li JY
LA  - chi
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Interleukin-8)
RN  - 0 (RNA, Messenger)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Bone Marrow Cells/*metabolism
MH  - Cells, Cultured
MH  - Chemokine CCL2/metabolism
MH  - Chemokine CXCL12/metabolism
MH  - Chemotactic Factors/*metabolism
MH  - Hepatocyte Growth Factor/metabolism
MH  - Humans
MH  - Interleukin-8/metabolism
MH  - Mesenchymal Stem Cells/*metabolism
MH  - Multiple Myeloma/*metabolism
MH  - RNA, Messenger/genetics
EDAT- 2011/03/03 06:00
MHDA- 2012/12/18 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 1009-2137(2011)01-0059-05 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Feb;19(1):59-63.