PMID- 21362224
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Feb
TI  - [Cytogenetic study on 53 patients with multiple myeloma].
PG  - 68-72
AB  - To explore the conventional cytogenetic (CC) characteristics and the partial 
      molecular cytogenetic characteristics of multiple myeloma (MM), R banding 
      technique was used for karyotype analysis in 53 cases of MM, and fluorescence in 
      situ hybridization(FISH) technique was used for molecular cytogenetic analysis in 
      20 cases out of them. The results showed that the rate of chromosome abnormality 
      was 32.1% in 53 cases. Among these abnormalities, 82.4% were involved in 3 or 
      more than 3 chromosome aberrations, the mode of chromosome was from 44 to 90. The 
      chromosome karyotype abnormality was involved in all of 24 chromosomes, and 70.6% 
      chromosome aberrations involved at least one of 1q21 amplification, 13q14 
      deletion, 17p13 deletion and 14q32 translocation. Some uncommon structural 
      aberrations were observed, such as t(11;16)(p11;p13) and some chromosome 
      abnormalities were often revealed in acute or chronic leukemia. FISH detection 
      showed that the results of 3 in 12 cases of MM with normal karyotype were 
      positive; the results of 5 in 8 cases of MM with abnormal karyotype were 
      positive. It is concluded that the abnormal chromosome karyotype was relatively 
      complex in most cases of MM showing obvious heterogenicity. Detected rate of 
      chromosome abnormalities in MM can be raised by FISH, though FISH technique has 
      its limitations. If CC analysis and FISH technique are combined, it will be 
      useful to raise the identification capability in detection of abnormal 
      chromosomes in the cytogenetic study of MM.
FAU - Jing, Yuan
AU  - Jing Y
AD  - Department of Hematology, Dalian Medical University, Dalian 116011, Liaoning 
      Province, China. jingyuanan@yahoo.com.cn
FAU - Fang, Mei-Yun
AU  - Fang MY
FAU - Jiang, Feng
AU  - Jiang F
FAU - Lin, Shuang
AU  - Lin S
FAU - Wang, Fang-Ting
AU  - Wang FT
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations
MH  - Cytogenetic Analysis/*methods
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics
EDAT- 2011/03/03 06:00
MHDA- 2012/12/18 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 1009-2137(2011)01-0068-05 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Feb;19(1):68-72.