PMID- 21362330
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20181201
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 124
IP  - 3
DP  - 2011 Feb
TI  - Association of defective HLA-I expression with antigen processing machinery and 
      their association with clinicopathological characteristics in Kazak patients with 
      esophageal cancer.
PG  - 341-6
AB  - BACKGROUND: It has been confirmed that defective expression of human leukocyte 
      antigen class I (HLA-I) molecules can contribute to the immune evasion of cancer 
      cells in some types of cancer. The aim of this study was to examine the 
      expression of HLA class I antigen and the antigen-processing machinery (APM) 
      components in esophageal squamous cell carcinoma (ESCC) and their role in high 
      risk human papillomavirus (HPV) infection, and to analyze their association with 
      histopathological characteristics in the Kazak ethnic group. METHODS: A total of 
      50 formalin-fixed, paraffin-embedded ESCC lesions were collected from the First 
      Affiliated Hospital of Xinjiang Medical University, China. The expression levels 
      of HLA-I antigen and APM components were determined by immunohistochemistry; the 
      HPV DNA were detected using polymerase chain reaction (PCR). RESULTS: A high 
      frequency of down-regulation or loss of expression of HLA and APM components were 
      found in esophageal cancer in Kazak people. HLA-I, TAP1, CNX, LMP7, Erp57, 
      Tapasin and ERAP1 were down-regulated in 68%, 44%, 48%, 40%, 52%, 32% and 20% of 
      ESCC lesions then, respectively. The loss of expression of HLA-I antigen was 
      significantly correlated with part of the APM components and positively 
      correlated with high risk HPV16 infection. TAP1, CNX, LMP7, Erp57 and Tapasin 
      loss were significantly associated with tumor grading, lymph node metastasis and 
      depth of invasion (P < 0.05). CONCLUSION: Our results suggest that APM component 
      defects are a mechanism underlying HLA-I antigen down-regulation in ESCC lesions, 
      and indicate that the loss expression of HLA-I and APM components will become an 
      important marker of ESCC and analysis of HLA-I and APM component expression can 
      provide useful prognostic information for patients with ESCC from the Kazak 
      ethnic group.
FAU - Ayshamgul, Hasim
AU  - Ayshamgul H
AD  - Department of Thoracic Surgery, First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, Xinjiang 830054, China.
FAU - Ma, Hong
AU  - Ma H
FAU - Ilyar, Sheyhidin
AU  - Ilyar S
FAU - Zhang, Li-Wei
AU  - Zhang LW
FAU - Abulizi, Abudula
AU  - Abulizi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (TAP1 protein, human)
RN  - 0 (tapasin)
RN  - 139873-08-8 (Calnexin)
RN  - EC 3.4.11.- (Aminopeptidases)
RN  - EC 3.4.11.- (ERAP1 protein, human)
RN  - EC 3.4.25.1 (LMP7 protein)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
RN  - EC 5.3.4.1 (Protein Disulfide-Isomerases)
RN  - EC 5.3.4.1. (PDIA3 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP-Binding Cassette Transporters/genetics/metabolism
MH  - Adult
MH  - Aged
MH  - Aminopeptidases/genetics/metabolism
MH  - Antigen Presentation/genetics/*physiology
MH  - Calnexin/genetics/metabolism
MH  - Esophageal Neoplasms/*metabolism
MH  - Female
MH  - Histocompatibility Antigens Class I/genetics/*metabolism
MH  - Human papillomavirus 16/genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - In Vitro Techniques
MH  - Male
MH  - Membrane Transport Proteins/genetics/metabolism
MH  - Middle Aged
MH  - Minor Histocompatibility Antigens
MH  - Polymerase Chain Reaction
MH  - Proteasome Endopeptidase Complex/genetics/metabolism
MH  - Protein Disulfide-Isomerases/genetics/metabolism
EDAT- 2011/03/03 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2011 Feb;124(3):341-6.