PMID- 21364890
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20240316
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Feb 25
TI  - Impaired resting-state functional integrations within default mode network of 
      generalized tonic-clonic seizures epilepsy.
PG  - e17294
LID - 10.1371/journal.pone.0017294 [doi]
LID - e17294
AB  - Generalized tonic-clonic seizures (GTCS) are characterized by unresponsiveness 
      and convulsions, which cause complete loss of consciousness. Many recent studies 
      have found that the ictal alterations in brain activity of the GTCS epilepsy 
      patients are focally involved in some brain regions, including thalamus, upper 
      brainstem, medial prefrontal cortex, posterior midbrain regions, and lateral 
      parietal cortex. Notably, many of these affected brain regions are the same and 
      overlap considerably with the components of the so-called default mode network 
      (DMN). Here, we hypothesize that the brain activity of the DMN of the GTCS 
      epilepsy patients are different from normal controls, even in the resting state. 
      To test this hypothesis, we compared the DMN of the GTCS epilepsy patients and 
      the controls using the resting state functional magnetic resonance imaging. 
      Thirteen brain areas in the DMN were extracted, and a complete undirected 
      weighted graph was used to model the DMN for each participant. When directly 
      comparing the edges of the graph, we found significant decreased functional 
      connectivities within the DMN of the GTCS epilepsy patients comparing to the 
      controls. As for the nodes of the graph, we found that the degree of some brain 
      areas within the DMN was significantly reduced in the GTCS epilepsy patients, 
      including the anterior medial prefrontal cortex, the bilateral superior frontal 
      cortex, and the posterior cingulate cortex. Then we investigated into possible 
      mechanisms of how GTCS epilepsy could cause the reduction of the functional 
      integrations of DMN. We suggested the damaged functional integrations of the DMN 
      in the GTCS epilepsy patients even during the resting state, which could help to 
      understand the neural correlations of the impaired consciousness of GTCS epilepsy 
      patients.
FAU - Song, Ming
AU  - Song M
AD  - National Laboratory of Pattern Recognition, Institute of Automation, Chinese 
      Academy of Sciences, Beijing, China.
FAU - Du, Hanjian
AU  - Du H
FAU - Wu, Nan
AU  - Wu N
FAU - Hou, Bing
AU  - Hou B
FAU - Wu, Guocai
AU  - Wu G
FAU - Wang, Jian
AU  - Wang J
FAU - Feng, Hua
AU  - Feng H
FAU - Jiang, Tianzi
AU  - Jiang T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110225
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Brain/anatomy & histology/*physiopathology
MH  - Brain Mapping/methods
MH  - Case-Control Studies
MH  - Epilepsy/*physiopathology/psychology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - Rest/*physiology/psychology
MH  - Seizures/*physiopathology/psychology
MH  - Young Adult
PMC - PMC3045438
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/03/03 06:00
MHDA- 2011/09/02 06:00
PMCR- 2011/02/25
CRDT- 2011/03/03 06:00
PHST- 2010/09/30 00:00 [received]
PHST- 2011/01/28 00:00 [accepted]
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PHST- 2011/02/25 00:00 [pmc-release]
AID - PONE-D-10-02773 [pii]
AID - 10.1371/journal.pone.0017294 [doi]
PST - epublish
SO  - PLoS One. 2011 Feb 25;6(2):e17294. doi: 10.1371/journal.pone.0017294.