PMID- 21365951
OWN - NLM
STAT- MEDLINE
DCOM- 20110512
LR  - 20161125
IS  - 1427-440X (Print)
IS  - 1427-440X (Linking)
VI  - 56 Suppl 1
DP  - 2010
TI  - [Mycophenolate mofetil for the treatment of lupus nephritis. The case of lupus 
      nephritis--class IV according to WHO--treated with mycophenolate mofetil].
PG  - 91-4
AB  - BACKGROUND: Lupus nephritis (LN) develops in almost 60% of patients with systemic 
      lupus erythematosus. In its most severe proliferative forms, LN often leads to 
      end-stage renal failure. Therapeutic regimens in severe lupus nephropathies, 
      especially class IV according to WHO, are based on glucocorticosteroids (GCSs) 
      administered together with cyclophosphamide (CPA) as the first-line drugs. New 
      therapeutic options appeared once immunosuppressive properties of mycophenolic 
      acid derivatives (mycophenolate mofetil) were documented. CASE REPORT: We 
      describe a patient with LN class IV treated according to various 
      immunosuppressive protocols adjusted to the degree of LN activity. The 
      remission-inducing protocol based on intravenous pulses of GCSs and CPA resulted 
      in regression of renal lesions but was associated with the risk of complications. 
      Mycophenolate mofetil was found effective for maintenance therapy. CONCLUSION: 
      The choice of therapy for patients with LN should be based on the severity of 
      renal disease at the time of diagnosis and on the histopathology of the renal 
      bioptate. Discrepancies obtain as to first-line drugs for severe forms of LN and 
      duration of remission-inducing therapy.
FAU - Suszek, Dorota
AU  - Suszek D
AD  - Katedra i Klinika Reumatologii i Ukladowych Chorob Tkanki Lacznej Uniwersytetu 
      Medycznego w Lublinie ul. Jaczewskiego 8, 20-950 Lublin.
FAU - Wielosz, Ewa
AU  - Wielosz E
FAU - Majdan, Maria
AU  - Majdan M
LA  - pol
PT  - Case Reports
PT  - Journal Article
TT  - Mycofenolan mofetylu w leczeniu toczniowego zapalenia nerek. Przypadek chorej na 
      toczniowe zapalenie nerek--klasa IV wedlug WHO leczonej mykofenolatem mofetylu.
PL  - Poland
TA  - Ann Acad Med Stetin
JT  - Annales Academiae Medicae Stetinensis
JID - 7506854
RN  - 0 (Immunosuppressive Agents)
RN  - HU9DX48N0T (Mycophenolic Acid)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Lupus Nephritis/*classification/*drug therapy
MH  - Mycophenolic Acid/*analogs & derivatives/therapeutic use
MH  - Young Adult
EDAT- 2010/01/01 00:00
MHDA- 2011/05/13 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/05/13 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Stetin. 2010;56 Suppl 1:91-4.