PMID- 21368166
OWN - NLM
STAT- MEDLINE
DCOM- 20110516
LR  - 20220318
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 108
IP  - 11
DP  - 2011 Mar 15
TI  - Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc 
      receptor (FcRn) confers protective immunity to vaginal infection.
PG  - 4388-93
LID - 10.1073/pnas.1012861108 [doi]
AB  - IgG is a major Ig subclass in mucosal secretions of the human female genital 
      tract, where it predominates over the IgA isotype. Despite the abundance of IgG, 
      surprisingly little is known about where and how IgG enters the lumen of the 
      genital tract and the exact role local IgG plays in preventing sexually 
      transmitted diseases. We demonstrate here that the neonatal Fc receptor, FcRn, is 
      expressed in female genital tract epithelial cells of humans and mice and binds 
      IgG in a pH-dependent manner. In vitro we show that FcRn mediates bidirectional 
      IgG transport across polarized human endometrial HEC-1-A monolayers and primary 
      human genital epithelial cells. Furthermore, endosomal acidification appears to 
      be a prerequisite for FcRn-mediated IgG transcytosis; IgG transcytosis was 
      demonstrated in vivo by translocation of systemically administered IgG into the 
      genital lumen in WT but not FcRn-KO mice. The biological relevance of 
      FcRn-transported IgG was demonstrated by passive immunization using herpes 
      simplex virus-2 (HSV-2)-specific polyclonal serum, which conferred significantly 
      higher protection against intravaginal challenge infection by the HSV-2 186 
      strain in WT mice than in FcRn-KO mice. These studies demonstrate that 
      FcRn-mediated transport is a mechanism by which IgG can act locally in the female 
      genital tract in immune surveillance and in host defense against sexually 
      transmitted diseases.
FAU - Li, Zili
AU  - Li Z
AD  - Laboratory of Immunology, Virginia-Maryland Regional College of Veterinary 
      Medicine, College Park, MD 20742, USA.
FAU - Palaniyandi, Senthilkumar
AU  - Palaniyandi S
FAU - Zeng, Rongyu
AU  - Zeng R
FAU - Tuo, Wenbin
AU  - Tuo W
FAU - Roopenian, Derry C
AU  - Roopenian DC
FAU - Zhu, Xiaoping
AU  - Zhu X
LA  - eng
GR  - R21 AI067965/AI/NIAID NIH HHS/United States
GR  - R01 AI065892/AI/NIAID NIH HHS/United States
GR  - AI67965/AI/NIAID NIH HHS/United States
GR  - DK56597/DK/NIDDK NIH HHS/United States
GR  - AI65892/AI/NIAID NIH HHS/United States
GR  - AI73139/AI/NIAID NIH HHS/United States
GR  - R01 DK056597/DK/NIDDK NIH HHS/United States
GR  - R21 AI073139/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110228
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antibodies, Viral)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Fc)
RN  - TW3XAW0RCY (Fc receptor, neonatal)
SB  - IM
CIN - Nat Rev Immunol. 2011 Apr;11(4):234-5. PMID: 21553710
MH  - Animals
MH  - Antibodies, Viral/pharmacology/therapeutic use
MH  - Cell Line
MH  - Epithelial Cells/drug effects/metabolism/pathology
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Herpesvirus 2, Human/drug effects/immunology
MH  - Histocompatibility Antigens Class I/genetics/*immunology/metabolism
MH  - Humans
MH  - Immunity/drug effects/*immunology
MH  - Immunoglobulin G/*immunology
MH  - Mice
MH  - Protein Transport/drug effects
MH  - Receptors, Fc/genetics/metabolism
MH  - *Transcytosis/drug effects
MH  - Vagina/drug effects/*metabolism/pathology
MH  - Vaginal Diseases/drug therapy/*immunology/*prevention & control/virology
PMC - PMC3060240
COIS- The authors declare no conflict of interest.
EDAT- 2011/03/04 06:00
MHDA- 2011/05/17 06:00
PMCR- 2011/09/15
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/05/17 06:00 [medline]
PHST- 2011/09/15 00:00 [pmc-release]
AID - 1012861108 [pii]
AID - 201012861 [pii]
AID - 10.1073/pnas.1012861108 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4388-93. doi: 
      10.1073/pnas.1012861108. Epub 2011 Feb 28.