PMID- 21368270
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20211020
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 300
IP  - 6
DP  - 2011 Jun
TI  - High-fat diet offsets the long-lasting effects of running-wheel access on food 
      intake and body weight in OLETF rats.
PG  - R1459-67
LID - 10.1152/ajpregu.00517.2010 [doi]
AB  - We have previously demonstrated that running-wheel access normalizes the food 
      intake and body weight of Otsuka Long-Evens Tokushima Fatty (OLETF) rats. 
      Following 6 wk of running-wheel access beginning at 8 wk of age, the body weight 
      of OLETF rats remains reduced, demonstrating a lasting effect on their phenotype. 
      In contrast, access to a high-fat diet exacerbates the hyperphagia and obesity of 
      OLETF rats. To determine whether diet modulates the long-term effects of 
      exercise, we examined the effects of high-fat diet on food intake and body weight 
      in OLETF rats that had prior access to running wheels for 4 wk. We found that 4 
      wk of running exercise significantly decreased food intake and body weight of 
      OLETF rats. Consistent with prior results, 4 wk of exercise also produced 
      long-lasting effects on food intake and body weight in OLETF rats fed a regular 
      chow. When running wheels were relocked, OLETF rats stabilized at lower levels of 
      body weight than sedentary OLETF rats. However, access to a high-fat diet offset 
      these effects. When OLETF rats were switched to a high-fat diet following wheel 
      relocking, they significantly increased food intake and body weight, so that they 
      reached levels similar to those of sedentary OLETF rats fed a high-fat diet. Gene 
      expression determination of hypothalamic neuropeptides revealed changes that 
      appeared to be appropriate responses to the effects of diet and running exercise. 
      Together, these results demonstrate that high-fat diet modulates the long-lasting 
      effects of exercise on food intake and body weight in OLETF rats.
FAU - Chao, Pei-Ting
AU  - Chao PT
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, Maryland 21205, USA.
FAU - Terrillion, Chantelle E
AU  - Terrillion CE
FAU - Moran, Timothy H
AU  - Moran TH
FAU - Bi, Sheng
AU  - Bi S
LA  - eng
GR  - R01 DK074269-04S1/DK/NIDDK NIH HHS/United States
GR  - R01 DK074269/DK/NIDDK NIH HHS/United States
GR  - R01 DK074269-03/DK/NIDDK NIH HHS/United States
GR  - R01 DK074269-01A1/DK/NIDDK NIH HHS/United States
GR  - R01 DK074269-04/DK/NIDDK NIH HHS/United States
GR  - P30 DK079637/DK/NIDDK NIH HHS/United States
GR  - R01 DK074269-02/DK/NIDDK NIH HHS/United States
GR  - R01 DK074269-05/DK/NIDDK NIH HHS/United States
GR  - DK074269/DK/NIDDK NIH HHS/United States
GR  - DK557609/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110302
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (AGRP protein, rat)
RN  - 0 (Agouti-Related Protein)
RN  - 0 (Dietary Fats)
RN  - 0 (Leptin)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Adipose Tissue/physiopathology
MH  - Agouti-Related Protein/metabolism
MH  - Animals
MH  - Body Weight/*drug effects/*physiology
MH  - Corticotropin-Releasing Hormone/metabolism
MH  - Diabetes Mellitus, Type 2/blood/*physiopathology
MH  - Dietary Fats/*pharmacology
MH  - Disease Models, Animal
MH  - Eating/*drug effects/*physiology
MH  - Glucose Intolerance/physiopathology
MH  - Hypothalamus/metabolism
MH  - Leptin/blood
MH  - Male
MH  - Physical Conditioning, Animal/*physiology
MH  - Pro-Opiomelanocortin/metabolism
MH  - Rats
MH  - Rats, Inbred OLETF
MH  - Time Factors
PMC - PMC3119147
EDAT- 2011/03/04 06:00
MHDA- 2011/09/17 06:00
PMCR- 2012/06/01
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - ajpregu.00517.2010 [pii]
AID - R-00517-2010 [pii]
AID - 10.1152/ajpregu.00517.2010 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1459-67. doi: 
      10.1152/ajpregu.00517.2010. Epub 2011 Mar 2.