PMID- 21368772
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20211020
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 12
IP  - 6
DP  - 2011 Sep
TI  - The role of HLA-DR-DQ haplotypes in variable antibody responses to anthrax 
      vaccine adsorbed.
PG  - 457-65
LID - 10.1038/gene.2011.15 [doi]
AB  - Host genetic variation, particularly within the human leukocyte antigen (HLA) 
      loci, reportedly mediates heterogeneity in immune response to certain vaccines; 
      however, no large study of genetic determinants of anthrax vaccine response has 
      been described. We searched for associations between the immunoglobulin G 
      antibody to protective antigen (AbPA) response to Anthrax Vaccine Adsorbed (AVA) 
      in humans, and polymorphisms at HLA class I (HLA-A, -B, and -C) and class II 
      (HLA-DRB1, -DQA1, -DQB1, -DPB1) loci. The study included 794 European-Americans 
      and 200 African-Americans participating in a 43-month, double-blind and 
      placebo-controlled clinical trial of AVA (clinicaltrials.gov identifier 
      NCT00119067). Among European-Americans, genes from tightly linked HLA-DRB1, 
      -DQA1, -DQB1 haplotypes displayed significant overall associations with 
      longitudinal variation in AbPA levels at 4, 8, 26 and 30 weeks from baseline in 
      response to vaccination with three or four doses of AVA (global P=6.53 x 10(-4)). 
      In particular, carriage of the DRB1-DQA1-DQB1 haplotypes (*)1501-(*)0102-(*)0602 
      (P=1.17 x 10(-5)), (*)0101-(*)0101-(*)0501 (P=0.009) and (*)0102-(*)0101-(*)0501 
      (P=0.006) was associated with significantly lower AbPA levels. In carriers of two 
      copies of these haplotypes, lower AbPA levels persisted following subsequent 
      vaccinations. No significant associations were observed amongst African-Americans 
      or for any HLA class I allele/haplotype. Further studies will be required to 
      replicate these findings and to explore the role of host genetic variation 
      outside of the HLA region.
FAU - Pajewski, N M
AU  - Pajewski NM
AD  - Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, 
      AL 35294-0022, USA.
FAU - Parker, S D
AU  - Parker SD
FAU - Poland, G A
AU  - Poland GA
FAU - Ovsyannikova, I G
AU  - Ovsyannikova IG
FAU - Song, W
AU  - Song W
FAU - Zhang, K
AU  - Zhang K
FAU - McKinney, B A
AU  - McKinney BA
FAU - Pankratz, V S
AU  - Pankratz VS
FAU - Edberg, J C
AU  - Edberg JC
FAU - Kimberly, R P
AU  - Kimberly RP
FAU - Jacobson, R M
AU  - Jacobson RM
FAU - Tang, J
AU  - Tang J
FAU - Kaslow, R A
AU  - Kaslow RA
LA  - eng
SI  - ClinicalTrials.gov/NCT00119067
GR  - N01 AI040068/AI/NIAID NIH HHS/United States
GR  - N01AI40068/AI/NIAID NIH HHS/United States
GR  - T32 HL072757/HL/NHLBI NIH HHS/United States
GR  - T32 HL072757-09/HL/NHLBI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110303
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (Anthrax Vaccines)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Anthrax/immunology
MH  - Anthrax Vaccines/*immunology
MH  - Antibody Formation/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Variation
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/genetics
MH  - Humans
MH  - Immunoglobulin G/biosynthesis/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
PMC - PMC3165112
MID - NIHMS297849
EDAT- 2011/03/04 06:00
MHDA- 2012/01/28 06:00
PMCR- 2012/03/01
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - gene201115 [pii]
AID - 10.1038/gene.2011.15 [doi]
PST - ppublish
SO  - Genes Immun. 2011 Sep;12(6):457-65. doi: 10.1038/gene.2011.15. Epub 2011 Mar 3.