PMID- 21370144
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110303
IS  - 1543-1894 (Print)
IS  - 1543-1894 (Linking)
VI  - 49
DP  - 2001
TI  - Direct molecular diagnosis of multiple endocrine neoplasia type 1.
PG  - 227-42
LID - 10.1385/1-59259-081-0:227 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome 
      characterized by the predisposition to develop both peptic ulcer disease and a 
      wide variety of endocrine tumors usually in adolescence and adulthood. 
      Specifically, hyperplasia and/or tumors (most often adenomas) of the parathyroid, 
      pancreatic islet cells, anterior pituitary, and adrenal cortical glands are 
      classically described in affected individuals who have MEN1 (1,2). MEN1 is a 
      highly penetrant disorder whose onset is generally during adult life with the 
      occurrence of at least one, but most often more than one, of the aforementioned 
      tumors. The age-related penetrance of this disorder based on analysis in 63 
      unrelated kindreds is 7, 52, 87, 98, 99, and 100% by 10, 20, 30, 40, 50, and 60 
      yr, respectively (3). The disorder is estimated to occur in approx 1 in 30,000 to 
      1 in 50,000 individuals. Most cases are associated with a positive family history 
      of the disorder, but new germline mutations have been identified in a small 
      percentage of individuals having a negative family history of the disorder but 
      classic features of MEN1 (3-7).
FAU - Petty, E M
AU  - Petty EM
AD  - Department of Human Genetics, University of Michigan, Ann Arbor, MI.
FAU - Glynn, M
AU  - Glynn M
FAU - Bale, A E
AU  - Bale AE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Med
JT  - Methods in molecular medicine
JID - 101123138
EDAT- 2001/01/01 00:00
MHDA- 2001/01/01 00:01
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2001/01/01 00:00 [pubmed]
PHST- 2001/01/01 00:01 [medline]
AID - 10.1385/1-59259-081-0:227 [doi]
PST - ppublish
SO  - Methods Mol Med. 2001;49:227-42. doi: 10.1385/1-59259-081-0:227.