PMID- 21371121
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20171116
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 26
IP  - 6
DP  - 2011 Jun
TI  - Vagal activities are involved in antigen-specific immune inflammation in the 
      intestine.
PG  - 1065-71
LID - 10.1111/j.1440-1746.2011.06710.x [doi]
AB  - BACKGROUND AND AIMS: The mechanism of intestinal immune inflammation, such as 
      food allergy, remains to be further understood. The present study aims to 
      investigate the role of the vagal nerve in the pathogenesis of skewed T-helper 2 
      (Th2) responses in the intestine. METHODS: The expression of the immunoglobulin E 
      (IgE) receptor on the vagus nerve in the mouse intestine was observed by 
      immunohistochemistry. Vagus ganglion neurons (VGN) were isolated from mice and 
      cultured in vitro. The IgE receptor/IgE complex on vagus neurons was examined by 
      immune precipitation assay. A food allergy mouse model was developed; the effect 
      of the partial removal of the vagal nerve (PRVn) via surgery or administration 
      with anticholinergic agents on the suppression of Th2 inflammation was evaluated. 
      RESULTS: The high-affinity IgE receptor was detected on the intestinal vagus 
      nerve. An increase in the expression of the IgE receptor on the vagus nerve was 
      observed in the intestines of mice with intestinal immune inflammation. Isolated 
      mouse VGN express IgE receptor I, which could form complexes with IgE. 
      Re-exposure to specific antigens activated the sensitized VGN, manifesting the 
      release of transmitter glutamate that could activate dendritic cells by 
      increasing the expression of CD80 and major compatibility complex class II and 
      suppressing interleukin-12. The PRVn suppressed Th2 inflammation in the 
      intestine. CONCLUSIONS: The intestinal vagus nerve in mice expresses a 
      high-affinity IgE receptor. An antigen-specific immune response can activate the 
      vagus nerve in the intestine and induces the release of transmitters to modulate 
      dendritic cell phenotypes that facilitate the development of skewed Th2 
      polarization in the intestine.
CI  - (c) 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell 
      Publishing Asia Pty Ltd.
FAU - Liang, Hong
AU  - Liang H
AD  - Department of Neurosurgery, Daping Hospital of the Third Military Medical 
      University, Yuzhong District, Chongqing, China.
FAU - Xu, Lunshan
AU  - Xu L
FAU - Zhou, Chun
AU  - Zhou C
FAU - Zhang, Yihua
AU  - Zhang Y
FAU - Xu, Minhui
AU  - Xu M
FAU - Zhang, Chengqu
AU  - Zhang C
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (B7-1 Antigen)
RN  - 0 (Cholinergic Antagonists)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Receptors, IgE)
RN  - 187348-17-0 (Interleukin-12)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - B7-1 Antigen/metabolism
MH  - Cells, Cultured
MH  - Cholinergic Antagonists/pharmacology
MH  - Dendritic Cells/immunology
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Food Hypersensitivity/*immunology/physiopathology/prevention & control
MH  - Ganglia, Parasympathetic/*immunology/metabolism/physiopathology
MH  - Glutamic Acid/metabolism
MH  - Histocompatibility Antigens Class II/metabolism
MH  - Immunoglobulin E/*metabolism
MH  - Immunohistochemistry
MH  - Inflammation/*immunology/physiopathology/prevention & control
MH  - Interleukin-12/metabolism
MH  - Intestines/*innervation
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin
MH  - Receptors, IgE/*metabolism
MH  - Th2 Cells/immunology
MH  - Vagotomy
MH  - Vagus Nerve/drug effects/*immunology/metabolism/physiopathology/surgery
EDAT- 2011/03/05 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - 10.1111/j.1440-1746.2011.06710.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2011 Jun;26(6):1065-71. doi: 
      10.1111/j.1440-1746.2011.06710.x.