PMID- 21371348
OWN - NLM
STAT- MEDLINE
DCOM- 20120210
LR  - 20220129
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Feb 28
TI  - In vivo approaches to investigate ANCA-associated vasculitis: lessons and 
      limitations.
PG  - 204
LID - 10.1186/ar3236 [doi]
AB  - Anti-neutrophil cytoplasm autoantibody (ANCA)-associated diseases are autoimmune 
      conditions characterized by necrotizing inflammation of small blood vessels. The 
      immunogenesis and etiology of these conditions are unknown, but our knowledge of 
      the immunopathogenesis has increased considerably in recent years. In this 
      review, we discuss the animal models currently used to investigate the mechanisms 
      of vascular injury and to test novel therapies. We outline their advantages and 
      limitations and propose potential directions for future research.
FAU - Heeringa, Peter
AU  - Heeringa P
AD  - Department of Pathology and Medical Biology, University Medical Centre Groningen, 
      University of Groningen, Hanzeplein 1 EA11, 9713 GZ, Groningen, The Netherlands. 
      p.heeringa@med.umcg.nl
FAU - Little, Mark A
AU  - Little MA
LA  - eng
GR  - G0801025/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110228
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
SB  - IM
MH  - Animals
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*drug 
      therapy/*immunology/*pathology
MH  - Disease Models, Animal
PMC - PMC3157641
EDAT- 2011/03/05 06:00
MHDA- 2012/02/11 06:00
PMCR- 2011/08/28
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2012/02/11 06:00 [medline]
PHST- 2011/08/28 00:00 [pmc-release]
AID - ar3236 [pii]
AID - 10.1186/ar3236 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2011 Feb 28;13(1):204. doi: 10.1186/ar3236.