PMID- 21371512
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20110708
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 63
IP  - 8
DP  - 2011 Jul 18
TI  - Myocardial regeneration: Roles of stem cells and hydrogels.
PG  - 688-97
LID - 10.1016/j.addr.2011.02.007 [doi]
AB  - Heart failure remains the leading cause of morbidity and mortality. Recently, it 
      was reported that the adult heart has intrinsic regenerative capabilities, 
      prompting a great wave of research into applying cell-based therapies, especially 
      with skeletal myoblasts and bone marrow-derived cells, to regenerate heart 
      tissues. While the mechanism of action for the observed beneficial effects of 
      bone marrow-derived cells remains unclear, new cell candidates are emerging, 
      including embryonic stem (ES) and introduced pluripotent stem (iPS) cells, as 
      well as cardiac stem cells (CSCs) from adult hearts. However, the very low 
      engraftment efficiency and survival of implanted cells prevent cell therapy from 
      turning into a clinical reality. Injectable hydrogel biomaterials based on 
      hydrophilic, biocompatible polymers and peptides have great potential for 
      addressing many of these issues by serving as cell/drug delivery vehicles and as 
      a platform for cardiac tissue engineering. In this review, we will discuss the 
      application of stem cells and hydrogels in myocardial regeneration.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Ye, Zhaoyang
AU  - Ye Z
AD  - The State Key Laboratory of Bioreactor Engineering, East China University of 
      Science and Technology, Shanghai 200237, China.
FAU - Zhou, Yan
AU  - Zhou Y
FAU - Cai, Haibo
AU  - Cai H
FAU - Tan, Wensong
AU  - Tan W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110301
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (Biocompatible Materials)
RN  - 0 (Hydrogels)
RN  - 0 (Polymers)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/administration & dosage
MH  - Cell Survival
MH  - Heart Failure/pathology/*therapy
MH  - Humans
MH  - Hydrogels
MH  - Myocardium/*metabolism/pathology
MH  - Polymers/administration & dosage
MH  - *Regeneration
MH  - Stem Cell Transplantation/methods
MH  - Tissue Engineering/methods
EDAT- 2011/03/05 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/03/05 06:00
PHST- 2010/11/03 00:00 [received]
PHST- 2011/02/23 00:00 [revised]
PHST- 2011/02/23 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0169-409X(11)00042-1 [pii]
AID - 10.1016/j.addr.2011.02.007 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2011 Jul 18;63(8):688-97. doi: 10.1016/j.addr.2011.02.007. 
      Epub 2011 Mar 1.