PMID- 21371524
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20151119
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 494
IP  - 1
DP  - 2011 Apr 20
TI  - Usefulness of serum S100B as a marker for the acute phase of aquaporin-4 
      autoimmune syndrome.
PG  - 86-8
LID - 10.1016/j.neulet.2011.02.063 [doi]
AB  - The aquaporin-4 (AQP4) water channel antibody is used in the diagnosis of 
      neuromyelitis optica (NMO) due to its high sensitivity and high specificity. 
      However, some patients are reported to have neither optic neuritis nor myelitis 
      despite being positive for the AQP4-autoantibody (AQP4-Ab). Therefore, recent 
      reports suggest that such patients should be diagnosed as having 'AQP4-autoimmune 
      syndrome'. In this study, we quantified the levels of glial fibrillar acidic 
      protein (GFAP) and S100B by enzyme-linked immunosorbent assay (ELISA) in CSF and 
      serum samples simultaneously obtained in the acute phase of ten AQP4-autoantibody 
      (AQP4Ab)-positive and seven AQP4Ab-negative patients. Serum levels of S100B were 
      significantly higher in the acute phase of the AQP4Ab-positive patients 
      (2.92+/-1.22pg/ml) than in the AQP4Ab-negative patients (0.559+/-0.180pg/ml, 
      p=0.0250), while serum levels of GFAP were not different between the two groups 
      (AQP4Ab-positive vs. AQP4Ab-negative: 0.120+/-0.113ng/ml vs. 0.00609+/-0.00609ng/ml, 
      p=0.193). Furthermore, the CSF and serum levels of S100B had a significant 
      positive correlation in AQP4Ab-positive patients (n=10, r=0.673, p=0.0390). Our 
      results raise the possibility that serum levels of S100B, but not GFAP, examined 
      in the acute phase of the disease might be a useful biomarker for the relapse of 
      AQP4 autoimmune syndrome.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Fujii, Chihiro
AU  - Fujii C
AD  - Department of Neurology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, 
      Kamigyo-ku, Kyoto 602-8566, Japan. chihiro0612tsu@yahoo.co.jp
FAU - Tokuda, Takahiko
AU  - Tokuda T
FAU - Ishigami, Noriko
AU  - Ishigami N
FAU - Mizuno, Toshiki
AU  - Mizuno T
FAU - Nakagawa, Masanori
AU  - Nakagawa M
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Aquaporin 4)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100 Proteins)
RN  - 0 (S100B protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aquaporin 4/*immunology
MH  - Autoantibodies/blood/immunology
MH  - Autoimmune Diseases/*blood/cerebrospinal fluid/immunology
MH  - Biomarkers/blood/cerebrospinal fluid
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glial Fibrillary Acidic Protein/blood/cerebrospinal fluid/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factors/*blood/cerebrospinal fluid/immunology
MH  - S100 Calcium Binding Protein beta Subunit
MH  - S100 Proteins/*blood/cerebrospinal fluid/immunology
EDAT- 2011/03/05 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2010/12/20 00:00 [received]
PHST- 2011/02/21 00:00 [revised]
PHST- 2011/02/23 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - S0304-3940(11)00254-0 [pii]
AID - 10.1016/j.neulet.2011.02.063 [doi]
PST - ppublish
SO  - Neurosci Lett. 2011 Apr 20;494(1):86-8. doi: 10.1016/j.neulet.2011.02.063. Epub 
      2011 Mar 1.