PMID- 21371686
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20151119
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 107
IP  - 9
DP  - 2011 May 1
TI  - Usefulness of total lymphocyte count as predictor of outcome in patients with 
      chronic heart failure.
PG  - 1353-6
LID - 10.1016/j.amjcard.2010.12.049 [doi]
AB  - Low lymphocyte count has been considered a predictive marker of unfavorable 
      outcomes for patients with heart failure (HF). Baseline blood samples for 
      complete blood counts, differential counts, renal function tests. and lipid 
      profile were prospectively obtained to assess the association between lymphocyte 
      count and clinical outcomes in 305 patients with HF (average New York Heart 
      Association [NYHA] class 2.8). The mean follow-up duration was 4.7 years (range 8 
      months to 8.4 years), and 111 patients (36%) died during the follow-up period. 
      The mean lymphocyte count for the group was 1,803.64 +/- 740.3, and the mean left 
      ventricular ejection fraction (LVEF) was 37%. Patients with low lymphocyte counts 
      (<1,600 median count) after 8 years had significantly lower survival rates than 
      those with lymphocyte counts >/=1,600 (58% vs 72%, p=0.012). The prediction of 
      poorest survival was for patients in NYHA class III or IV and with lymphocyte 
      counts <1,600. Regression analysis showed that lymphocyte level, the LVEF, and 
      NYHA class were predictors of mortality. Of these, NYHA class was the most 
      prominent predictor, followed by lymphocyte count, which was even more 
      significant than the LVEF (hazard ratio 0.76, p=0.037). In conclusion, the 
      findings of this study demonstrate that total lymphocyte count is an important 
      prognostic factor, inversely associated with predicted mortality. Although the 
      total low lymphocyte count was correlated with a lower NYHA class and a lower 
      LVEF, it emerged as an independent death risk factor in patients with chronic HF.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Charach, Gideon
AU  - Charach G
AD  - Department of Internal Medicine C, Tel Aviv Sourasky Medical Center, Tel Aviv, 
      Israel. drcharach@012.net.il
FAU - Grosskopf, Itamar
AU  - Grosskopf I
FAU - Roth, Arie
AU  - Roth A
FAU - Afek, Arnon
AU  - Afek A
FAU - Wexler, Dov
AU  - Wexler D
FAU - Sheps, David
AU  - Sheps D
FAU - Weintraub, Moshe
AU  - Weintraub M
FAU - Rabinovich, Alexander
AU  - Rabinovich A
FAU - Keren, Gad
AU  - Keren G
FAU - George, Jacob
AU  - George J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110302
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/*blood/*diagnosis
MH  - Humans
MH  - *Lymphocyte Count
MH  - Male
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2011/03/05 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/03/05 06:00
PHST- 2010/10/10 00:00 [received]
PHST- 2010/12/31 00:00 [revised]
PHST- 2010/12/31 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - S0002-9149(11)00140-8 [pii]
AID - 10.1016/j.amjcard.2010.12.049 [doi]
PST - ppublish
SO  - Am J Cardiol. 2011 May 1;107(9):1353-6. doi: 10.1016/j.amjcard.2010.12.049. Epub 
      2011 Mar 2.