PMID- 21372351
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20211020
IS  - 1998-4049 (Electronic)
IS  - 1319-3767 (Print)
IS  - 1319-3767 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Mar-Apr
TI  - Discriminant value of Rome III questionnaire in dyspeptic patients.
PG  - 129-33
LID - 10.4103/1319-3767.77244 [doi]
AB  - BACKGROUND/AIM: Rome III criteria has modified the description of functional 
      dyspepsia (FD) and divided this into subgroups. However, the discriminative value 
      of Rome III questionnaire-based diagnosis of FD is yet to be determined. 
      OBJECTIVES: To evaluate the Rome III questionnaire for the diagnosis of FD and 
      whether it can discriminate between postprandial distress syndrome (PDS) and 
      epigastric pain syndrome (EPS) in patients with dyspeptic symptoms. PATIENTS AND 
      METHODS: Consecutive patients, who were not on proton pump inhibitors (PPI), were 
      asked to participate. Patients who have previously established acid peptic 
      disease or predominantly reflux symptoms or having alarm symptoms such as weight 
      loss and hematemesis were excluded. Rome III questionnaire for FD was used to 
      identify the patients as having FD and divide into its subgroups; PDS or EPS. 
      Gastro-duodenal biopsies, liver function tests and ultrasound were done to 
      establish the diagnosis of FD. RESULTS: Out of 272 patients with upper 
      gastrointestinal (GI) symptoms without alarm features, who were enrolled in the 
      study, a total of 191 (70%) fulfilled the criteria of FD based upon Rome III 
      questionnaire. EPS subgroup was found in 109 (57%), PDS in 17 (9%) patients, 
      overlap between EPS and PDS was present in 56 (29%) patients. Nine (5%) patients 
      remained indeterminate. Diagnosis of FD was established in 136/191 (71%) patients 
      only. Gastritis was present in 116 patients (85%), Duodenitis in 44 (32%) and 
      Helicobacter pylori infection in 70 (51%) patients. Among 55 patients (29%) who 
      had organic diseases, EPS was seen in 35 (64%), PDS in 5 (9%) and overlap in 15 
      (27%) patients. Underlying organic causes were gastric or duodenal ulcers in 14 
      patients, Barrett esophagus in five, chronic liver disease in seven, gall stones 
      in five, Giardiasis and celiac disease in three each. Gastric carcinoma, Crohns 
      disease and gastric polyps were seen in one patient each. CONCLUSION: This study 
      indicates that 30% of patients who fulfilled the Rome III criteria for FD 
      actually had organic disease. Almost one-third of patients with functional 
      dyspepsia did not qualify for one of the two subgroups of FD of Rome III. There 
      is also a need to further define the Rome III-based subgroups of FD for research 
      purpose.
FAU - Abid, Shahab
AU  - Abid S
AD  - Department of Medicine, Aga Khan University, Karachi, Pakistan. 
      shahab.abid@aku.edu
FAU - Siddiqui, Shaheryar
AU  - Siddiqui S
FAU - Jafri, Wasim
AU  - Jafri W
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - India
TA  - Saudi J Gastroenterol
JT  - Saudi journal of gastroenterology : official journal of the Saudi 
      Gastroenterology Association
JID - 9516979
SB  - IM
MH  - Abdominal Pain/*diagnosis/etiology
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Diagnosis, Differential
MH  - Discriminant Analysis
MH  - Dyspepsia/*diagnosis/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postprandial Period
MH  - Predictive Value of Tests
MH  - *Surveys and Questionnaires
MH  - Syndrome
PMC - PMC3099059
COIS- Conflict of Interest: None declared
EDAT- 2011/03/05 06:00
MHDA- 2011/07/27 06:00
PMCR- 2011/03/01
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - SaudiJGastroenterol_2011_17_2_129_77244 [pii]
AID - SJG-17-129 [pii]
AID - 10.4103/1319-3767.77244 [doi]
PST - ppublish
SO  - Saudi J Gastroenterol. 2011 Mar-Apr;17(2):129-33. doi: 10.4103/1319-3767.77244.