PMID- 21372547
OWN - NLM
STAT- MEDLINE
DCOM- 20111011
LR  - 20131121
IS  - 1424-8840 (Electronic)
IS  - 1424-8832 (Linking)
VI  - 37
IP  - 2-4
DP  - 2010
TI  - Serum and saliva sialic acid in periodontitis patients with and without 
      cardiovascular disease.
PG  - 67-71
LID - 10.1159/000321377 [doi]
AB  - Serum total sialic acid (sTSA) has recently been shown to be a cardiovascular 
      risk factor. However, there is little information about the role of sTSA and TSA 
      in saliva in periodontitis, a chronic and inflammatory disease known to be a risk 
      factor for cardiovascular disease (CVD). We aimed to investigate the changes in 
      sTSA and TSA levels in saliva in patients having both periodontitis and CVD 
      versus periodontitis patients without diagnosed CVD. The study group consisted of 
      26 patients with proven periodontitis and 26 controls with no diagnosed systemic 
      disease but periodontitis. sTSA and saliva TSA levels were determined by the 
      thiobarbituric acid method, and C-reactive protein (CRP) was evaluated by the 
      nephelometric method. The severity of periodontitis has been determined by the 
      community periodontal index of treatment needs (CPITN). TSA in blood and saliva 
      and CRP levels in blood were significantly increased in CVD patients compared 
      with the control group. CPITN ranged from 2 to 4 in both groups. Significant and 
      positive correlations were found between sTSA and saliva SA levels in patients 
      and controls and between tooth loss and TSA both in blood and saliva. Therefore, 
      TSA in saliva may be a useful marker similar to sTSA in CVD patients.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Oktay, Sehkar
AU  - Oktay S
AD  - Department of Basic Sciences, Faculty of Dentistry, Marmara University, Istanbul, 
      Turkey. nsehkar@yahoo.com
FAU - Basar, Isik
AU  - Basar I
FAU - Emekli-Alturfan, Ebru
AU  - Emekli-Alturfan E
FAU - Malali, Ezgi
AU  - Malali E
FAU - Elemek, Eser
AU  - Elemek E
FAU - Ayan, Faruk
AU  - Ayan F
FAU - Koldas, Lale
AU  - Koldas L
FAU - Noyan, Ulku
AU  - Noyan U
FAU - Emekli, Nesrin
AU  - Emekli N
LA  - eng
PT  - Journal Article
DEP - 20110302
PL  - Switzerland
TA  - Pathophysiol Haemost Thromb
JT  - Pathophysiology of haemostasis and thrombosis
JID - 101142710
RN  - 9007-41-4 (C-Reactive Protein)
RN  - GZP2782OP0 (N-Acetylneuraminic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - C-Reactive Protein/metabolism
MH  - Cardiovascular Diseases/complications/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - N-Acetylneuraminic Acid/*blood
MH  - Periodontitis/complications/*metabolism
MH  - Risk Factors
MH  - Saliva/*metabolism
EDAT- 2011/03/05 06:00
MHDA- 2011/10/12 06:00
CRDT- 2011/03/05 06:00
PHST- 2010/01/05 00:00 [received]
PHST- 2010/08/24 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/10/12 06:00 [medline]
AID - 000321377 [pii]
AID - 10.1159/000321377 [doi]
PST - ppublish
SO  - Pathophysiol Haemost Thromb. 2010;37(2-4):67-71. doi: 10.1159/000321377. Epub 
      2011 Mar 2.