PMID- 21376472
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20221207
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 37
IP  - 5
DP  - 2011 Aug
TI  - Association of HLA haplotype with keloids in Chinese Hans.
PG  - 794-9
LID - 10.1016/j.burns.2011.01.003 [doi]
AB  - Keloids are common abnormal raised fibroproliferative lesions that can occur 
      following even minor cutaneous trauma. Human leukocyte antigen (HLA) 
      polymorphisms have shown strong association with susceptibility to keloids with 
      different ethnic backgrounds. In this study, the polymerase chain reaction 
      sequence-specific primer method was used to analyze the distribution of HLA 
      haplotype in 192 patients with keloids and 252 healthy control individuals. 
      Controls were matched by gender, age, and race. We compared haplotype between the 
      two groups, and analyzed their association with keloids. The haplotype analysis 
      revealed that three new two-locus haplotypes including B*07-DQB1*0501, 
      B*07-DRB1*15, DQB1*0503-DRB1*15 (P<0.05) were associated with keloids, while two 
      extended haplotypes B*07-Cw*0802-DQB1*0501 (P=0.0063) and 
      Cw*0802-DQB1*0501-DRB1*15 (P=0.0121) were found to be related to keloids. This is 
      the first detailed report to elucidate HLA haplotypes associated with keloids. 
      Our results provide some information for future research on predisposing genes in 
      major histocompatibility complex (MHC) regions in Chinese patients with keloids. 
      In addition, the association of certain HLA haplotypes with susceptibility to 
      keloids would provide clues in choosing proper preventive strategies.
CI  - Crown Copyright (c) 2011. Published by Elsevier Ltd. All rights reserved.
FAU - Lu, Wen-Sheng
AU  - Lu WS
AD  - Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, 
      China, Hefei 230022, Anhui, China.
FAU - Zuo, Xian-Bo
AU  - Zuo XB
FAU - Wang, Zai-Xing
AU  - Wang ZX
FAU - Cai, Li-Qiong
AU  - Cai LQ
FAU - Zhu, Fei
AU  - Zhu F
FAU - Li, Yang
AU  - Li Y
FAU - Zheng, Hou-Feng
AU  - Zheng HF
FAU - Sun, Liang Dan
AU  - Sun LD
FAU - Yang, Sen
AU  - Yang S
FAU - Zhang, Xue-Jun
AU  - Zhang XJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110303
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/ethnology/*genetics
MH  - Child
MH  - Child, Preschool
MH  - China/ethnology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Keloid/ethnology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2011/03/08 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/05/20 00:00 [received]
PHST- 2010/12/07 00:00 [revised]
PHST- 2011/01/07 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0305-4179(11)00006-4 [pii]
AID - 10.1016/j.burns.2011.01.003 [doi]
PST - ppublish
SO  - Burns. 2011 Aug;37(5):794-9. doi: 10.1016/j.burns.2011.01.003. Epub 2011 Mar 3.