PMID- 21376715
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20221207
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 412
IP  - 11-12
DP  - 2011 May 12
TI  - The RANTES gene promoter polymorphisms are associated with the risk of 
      atherothrombotic cerebral infarction in Northern Han Chinese.
PG  - 1112-5
LID - 10.1016/j.cca.2011.02.033 [doi]
AB  - BACKGROUND: Regulated upon activation, normal T-cell expressed and secreted 
      (RANTES) plays an important role in the inflammatory process. This study is aimed 
      at evaluating the potential association of the -403G/A (rs2107538) and -28C/G 
      (rs2280788) polymorphisms of the RANTES gene promoter with the risk of 
      atherothrombotic cerebral infarction (ACI) in Northern Han Chinese. METHOD: A 
      total of 314 patients with ACI and 389 unrelated aged-matched healthy controls 
      were recruited. Their genotypes of the RANTES gene promoter -403G/A (rs2107538) 
      and -28C/G (rs2280788) were analyzed by multiplex polymerase chain reaction 
      (multiplex PCR) and multiplex SNaPshot analysis. The potential association of 
      genotyping and allele frequencies with ACI in this population was assessed 
      statistically. RESULTS: The frequencies of -403AA genotype and A allele in ACI 
      male patients were significantly higher than that in healthy controls (P=0.007, 
      P=0.009, respectively). Female patients were not different. Multiple logistic 
      regression analysis revealed that the -403AA genotype in males was significantly 
      associated with an increased risk of ACI, even after adjusting for confounding 
      factors (OR=4.344; 95% CI=1.969-9.582; P<0.001). Although there was no 
      significant association of the -28C/G polymorphism with ACI, the A-(403)C-(28) 
      haplotype was significantly associated with an increased risk of ACI in Han 
      Chinese [OR=1.56, 95% CI=1.23-1.98, P<0.001]. CONCLUSIONS: Our data suggest that 
      the -403AA genotype and A allele of the RANTES promoter were associated with 
      increased risk for the development of ACI in male Northern Han Chinese.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Qin, Xue
AU  - Qin X
AD  - Department of Neurology, The First Hospital of China Medical University, Shenyang 
      110001, China.
FAU - He, Zhiyi
AU  - He Z
FAU - Zhao, Dongxue
AU  - Zhao D
FAU - Li, Lei
AU  - Li L
FAU - Yuan, Liying
AU  - Yuan L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110303
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Chemokine CCL5)
SB  - IM
MH  - Asian People/*ethnology/genetics
MH  - Case-Control Studies
MH  - Cerebral Infarction/blood/complications/*genetics/pathology
MH  - Chemokine CCL5/*genetics
MH  - Ethnicity/genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Intracranial Thrombosis/*complications
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
EDAT- 2011/03/08 06:00
MHDA- 2012/08/09 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/11/24 00:00 [received]
PHST- 2011/02/23 00:00 [revised]
PHST- 2011/02/25 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - S0009-8981(11)00124-0 [pii]
AID - 10.1016/j.cca.2011.02.033 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2011 May 12;412(11-12):1112-5. doi: 10.1016/j.cca.2011.02.033. 
      Epub 2011 Mar 3.