PMID- 21377277
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20151119
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 207
IP  - 4
DP  - 2011 Apr 15
TI  - Immunopathological characteristics of immune reconstitution inflammatory syndrome 
      caused by Mycobacterium parascrofulaceum infection in a patient with AIDS.
PG  - 262-70
LID - 10.1016/j.prp.2011.01.003 [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) caused by mycobacterium in 
      patients with AIDS is often experienced in clinical practice. There is, however, 
      a paucity of data documenting the histopathological findings and the 
      pathogenesis. We determined the immunopathological characteristics of IRIS 
      associated with Mycobacterium parascrofulaceum infection in an AIDS patient. A 
      patient presented with pulmonary lymphadenitis and involvement of the pulmonary 
      lingular segment. Portions of the involved lymph nodes and lung were excised, and 
      the immunological properties were analyzed by immunohistochemical assays. The 
      histological characteristics of lymph nodes showed a caseous necrosis. 
      Histopathologically, the pulmonary lesion was composed of exudative and 
      proliferative lesions. CD4(+), CD8(+), CD57(+), and CD25(+)/FoxP3(+) cells were 
      observed in both types of lesions. Clusters of CD20(+) cells and GATA3(+) cells 
      were predominantly observed in exudative lesions, while T-bet(+) cells were 
      dominant in proliferative lesions. ROR-gamma(+) cells were also observed in exudative 
      lesions. These results indicate that the cellular immunity to mycobacteria was 
      recovering in the lung tissue. In M. parascrofulaceum pulmonary infection, the 
      exudative lesion had characteristics of Th2 and Th17-type immunities. In 
      contrast, the proliferative lesion had characteristics of Th-1 type immunity. Our 
      data provide the first evidence to reveal the status of the axis of distinctive 
      immunity in the process of granuloma formation caused by a mycobacterium-related 
      infection.
CI  - Copyright (c) 2011 Elsevier GmbH. All rights reserved.
FAU - Hibiya, Kenji
AU  - Hibiya K
AD  - Department of Infectious, Respiratory, and Digestive Medicine, Control and 
      Prevention of Infectious Diseases, Faculty of Medicine, University of the 
      Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. kenjihibiya@gmail.com
FAU - Tateyama, Masao
AU  - Tateyama M
FAU - Teruya, Hiromitsu
AU  - Teruya H
FAU - Nakamura, Hideta
AU  - Nakamura H
FAU - Tasato, Daisuke
AU  - Tasato D
FAU - Kazumi, Yuko
AU  - Kazumi Y
FAU - Hirayasu, Tsuneo
AU  - Hirayasu T
FAU - Tamaki, Yuichiro
AU  - Tamaki Y
FAU - Haranaga, Shusaku
AU  - Haranaga S
FAU - Higa, Futoshi
AU  - Higa F
FAU - Maeda, Shinji
AU  - Maeda S
FAU - Fujita, Jiro
AU  - Fujita J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110304
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Antibodies)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications/diagnosis
MH  - Acquired Immunodeficiency Syndrome/*complications/diagnosis
MH  - Adult
MH  - Antibodies
MH  - Antiretroviral Therapy, Highly Active
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*diagnosis/etiology/immunology
MH  - Immunohistochemistry
MH  - Lung/microbiology/pathology
MH  - Lymph Nodes/microbiology/pathology
MH  - Lymphatic Diseases/microbiology/pathology
MH  - Male
MH  - Mycobacterium Infections, Nontuberculous/*complications/diagnosis
MH  - Nontuberculous Mycobacteria/*pathogenicity
MH  - Respiratory Tract Infections/complications/diagnosis
MH  - Tomography, X-Ray Computed
EDAT- 2011/03/08 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/07/25 00:00 [received]
PHST- 2010/12/21 00:00 [revised]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - S0344-0338(11)00008-2 [pii]
AID - 10.1016/j.prp.2011.01.003 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2011 Apr 15;207(4):262-70. doi: 10.1016/j.prp.2011.01.003. Epub 
      2011 Mar 4.