PMID- 21377655
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20181201
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 70
IP  - 10
DP  - 2011 Nov 15
TI  - Early, time-dependent disturbances of hippocampal synaptic transmission and 
      plasticity after in utero immune challenge.
PG  - 992-9
LID - 10.1016/j.biopsych.2011.01.009 [doi]
AB  - BACKGROUND: Maternal infection during pregnancy is a recognized risk factor for 
      the occurrence of a broad spectrum of psychiatric and neurologic disorders, 
      including schizophrenia, autism, and cerebral palsy. Prenatal exposure of rats to 
      lipopolysaccharide (LPS) leads to impaired learning and psychotic-like behavior 
      in mature offspring, together with an enduring modification of glutamatergic 
      excitatory synaptic transmission. The question that arises is whether any 
      alterations of excitatory transmission and plasticity occurred at early 
      developmental stages after in utero LPS exposure. METHODS: Electrophysiological 
      experiments were carried out on the CA1 area of hippocampal slices from 
      prenatally LPS-exposed male offspring from 4 to 190 days old to study the 
      developmental profiles of long-term depression (LTD) triggered by delivering 900 
      shocks either single- or paired-pulse (50-msec interval) at 1 Hz and the 
      N-methyl-D-aspartate receptor (NMDAr) contribution to synaptic transmission. 
      RESULTS: The age-dependent drop of LTD is accelerated in prenatally LPS-exposed 
      animals, and LTD is transiently converted into a slow-onset long-term 
      potentiation between 16 and 25 days old. This long-term potentiation depends on 
      Group I metabotropic glutamate receptors and protein kinase A activations and is 
      independent of NMDArs. Maternal LPS challenge also leads to a rapid developmental 
      impairment of synaptic NMDArs. This was associated with a concomitant reduced 
      expression of GluN1, without any detectable alteration in the developmental 
      switch of NMDAr GluN2 subunits. CONCLUSIONS: Aberrant forms of synaptic 
      plasticity can be detected at early developmental stages after prenatal LPS 
      challenge concomitant with a clear hypo-functioning of the NMDAr in the 
      hippocampus. This might result in later-occurring brain dysfunctions.
CI  - Copyright (c) 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Escobar, Marion
AU  - Escobar M
AD  - Institut des Biomolecules Max Mousseron, Montpellier, France.
FAU - Crouzin, Nadine
AU  - Crouzin N
FAU - Cavalier, Melanie
AU  - Cavalier M
FAU - Quentin, Julie
AU  - Quentin J
FAU - Roussel, Julien
AU  - Roussel J
FAU - Lante, Fabien
AU  - Lante F
FAU - Batista-Novais, Aline Rideau
AU  - Batista-Novais AR
FAU - Cohen-Solal, Catherine
AU  - Cohen-Solal C
FAU - De Jesus Ferreira, Marie-Celeste
AU  - De Jesus Ferreira MC
FAU - Guiramand, Janique
AU  - Guiramand J
FAU - Barbanel, Gerard
AU  - Barbanel G
FAU - Vignes, Michel
AU  - Vignes M
LA  - eng
PT  - Journal Article
DEP - 20110305
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Polysaccharides)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 76326-31-3 (2-amino-5-phosphopentanoic acid)
RN  - 7VC0YVI27Y (6-methyl-2-(phenylethynyl)pyridine)
RN  - HG18B9YRS7 (Valine)
RN  - VH92ICR8HX (N-methyl D-aspartate receptor subtype 2A)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Biophysics
MH  - CA1 Region, Hippocampal/growth & development/pathology/*physiopathology
MH  - Electric Stimulation
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects/*physiology
MH  - Female
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - In Vitro Techniques
MH  - Long-Term Synaptic Depression/drug effects/*physiology
MH  - Male
MH  - Patch-Clamp Techniques
MH  - Polysaccharides/pharmacology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*pathology
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Valine/analogs & derivatives/pharmacology
EDAT- 2011/03/08 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/07/13 00:00 [received]
PHST- 2011/01/10 00:00 [revised]
PHST- 2011/01/11 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - S0006-3223(11)00030-8 [pii]
AID - 10.1016/j.biopsych.2011.01.009 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2011 Nov 15;70(10):992-9. doi: 10.1016/j.biopsych.2011.01.009. 
      Epub 2011 Mar 5.