PMID- 21377730
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20110718
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 35
IP  - 8
DP  - 2011 Aug
TI  - Evolutionary sequence of cytogenetic aberrations during the oncogenesis of plasma 
      cell disorders. Direct evidence at single cell level.
PG  - 1114-6
LID - 10.1016/j.leukres.2011.02.010 [doi]
AB  - Bone marrow specimens from 185 patients with plasma cell disorders (PCD) were 
      investigated by fluorescence in situ hybridization (FISH) in order to determine 
      the temporal sequence of cytogenetic aberrations. In 25 cases combined FISH 
      analysis has also been performed at single cell level. Clonal evolution was 
      observed in 16% of cases. The Delta13 was preceded by t(4;14)(p16;q32) and 
      t(14;16)(q32;q23) translocations. Deletion of p53 gene was a secondary aberration 
      compared to Delta13 and t(11;14)(q13;q32) translocation. In 22% of all cases with 
      recurrent IGH translocation, this aberration was presented only in a subset of 
      purified plasma cells questioning its initiating role.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Nagy, Zsofia
AU  - Nagy Z
AD  - Department of Pathology, University of Pecs, Pecs, Hungary.
FAU - Kajtar, Bela
AU  - Kajtar B
FAU - Jakso, Pal
AU  - Jakso P
FAU - David, Mariann
AU  - David M
FAU - Kosztolanyi, Szabolcs
AU  - Kosztolanyi S
FAU - Hermesz, Judit
AU  - Hermesz J
FAU - Kereskai, Laszlo
AU  - Kereskai L
FAU - Pajor, Laszlo
AU  - Pajor L
FAU - Alpar, Donat
AU  - Alpar D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110305
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Bone Marrow/metabolism/pathology
MH  - *Chromosome Aberrations
MH  - *Chromosome Disorders
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 16/genetics
MH  - Chromosomes, Human, Pair 4/genetics
MH  - *Evolution, Molecular
MH  - Humans
MH  - Immunoglobulin Heavy Chains/*genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Plasma Cell/*genetics/pathology
MH  - Multiple Myeloma/*genetics/pathology
MH  - Translocation, Genetic/genetics
EDAT- 2011/03/08 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/01/19 00:00 [received]
PHST- 2011/01/22 00:00 [revised]
PHST- 2011/02/08 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0145-2126(11)00072-5 [pii]
AID - 10.1016/j.leukres.2011.02.010 [doi]
PST - ppublish
SO  - Leuk Res. 2011 Aug;35(8):1114-6. doi: 10.1016/j.leukres.2011.02.010. Epub 2011 
      Mar 5.