PMID- 21379366
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1932-9520 (Print)
IS  - 1932-9563 (Electronic)
IS  - 1932-9520 (Linking)
VI  - 4
IP  - 4
DP  - 2010 Jul 1
TI  - Underdiagnosis of Metabolic Syndrome in Non-Hispanic Black Adolescents: A Call 
      for Ethnic-Specific Criteria.
PG  - 302-310
AB  - Childhood obesity is a risk factor for the development of both type 2 diabetes 
      mellitus (T2DM) and cardiovascular disease (CVD). One marker that can be used to 
      predict T2DM is the metabolic syndrome (MetS). MetS, a cluster of cardiovascular 
      factors associated with insulin resistance, is defined by central obesity, 
      impaired fasting glucose, hypertension, elevated triglycerides (TG), and low 
      levels of high-density lipoprotein cholesterol. Some have advocated using a 
      diagnosis of MetS to trigger increased intervention in children. However, ethnic 
      differences in MetS may hamper identification of at-risk children. For example, 
      non-Hispanic blacks are diagnosed with MetS less frequently than non-Hispanic 
      whites, despite having higher rates of T2DM and CVD. These differences in MetS 
      are predominantly due to a low frequency of hypertriglyceridemia in non-Hispanic 
      blacks. Compared with non-Hispanic whites and Mexican Americans, non-Hispanic 
      blacks have lower TG levels at baseline but exhibit worsening insulin resistance 
      with increasing TG. Therefore "normal" TG levels appear to be falsely reassuring 
      among insulin-resistant non-Hispanic blacks. Ethnic-specific tools may be needed 
      to more accurately predict risk for T2DM and CVD in minorities.
FAU - Deboer, Mark D
AU  - Deboer MD
AD  - Department of Pediatrics, Division of Pediatric Endocrinology, University of 
      Virginia School of Medicine, P.O. Box 800386, Charlottesville, VA 22908, USA.
LA  - eng
GR  - K08 HD060739/HD/NICHD NIH HHS/United States
GR  - K08 HD060739-01/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Curr Cardiovasc Risk Rep
JT  - Current cardiovascular risk reports
JID - 101463024
PMC - PMC3046404
MID - NIHMS270759
COIS- Disclosure No potential conflict of interest relevant to this article was 
      reported.
EDAT- 2011/03/08 06:00
MHDA- 2011/03/08 06:01
PMCR- 2011/07/01
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/03/08 06:01 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - 10.1007/s12170-010-0104-x [doi]
PST - ppublish
SO  - Curr Cardiovasc Risk Rep. 2010 Jul 1;4(4):302-310. doi: 
      10.1007/s12170-010-0104-x.