PMID- 2138052
OWN - NLM
STAT- MEDLINE
DCOM- 19900426
LR  - 20131121
IS  - 0828-282X (Print)
IS  - 0828-282X (Linking)
VI  - 6
IP  - 2
DP  - 1990 Mar
TI  - Antioxidant protection against adrenaline-induced arrhythmias in rats with 
      chronic heart hypertrophy.
PG  - 71-4
AB  - Effects of vitamin E on adrenaline-induced arrhythmias were examined in rats with 
      chronic heart hypertrophy subsequent to narrowing of the abdominal aorta. After 
      60 weeks of pressure overload, the rats showed an increase of about 21% in 
      heart/body weight ratio and a small but significant rise in left ventricular end 
      diastolic pressure (LVEDP) (sham control 1.7 +/- 0.67 mmHg; hypertrophy 7.1 +/- 
      2.7 mmHg) without any change in left ventricular peak systolic pressure (LVSP). 
      Intravenous infusion of adrenaline caused rhythm disorders in a dose-dependent 
      manner and pathological arrhythmias (occurrence of six premature ventricular 
      complexes/min) were observed at doses of 2.9 +/- 0.6 and 3.8 +/- 1.0 
      micrograms/kg of the drug in control and hypertrophy animals, respectively. 
      Administration of two doses of vitamin E (50 mg/kg intraperitoneally), given 24 h 
      and 1 h before adrenaline infusion, significantly increased the amount of 
      adrenaline required to produce pathological arrhythmias (control 8.0 +/- 3.0; 
      hypertrophy 7.7 +/- 2.0 micrograms/kg). Vitamin E pretreatment did not have any 
      detrimental effect on the pressure readings nor did it have any influence on 
      adrenaline-induced pressure changes. The data suggest that a combination therapy 
      with vitamin E may allow therapeutic use of higher concentrations of adrenaline 
      required to improve function in failing hearts with a reduced risk of 
      arrhythmias.
FAU - Kirshenbaum, L A
AU  - Kirshenbaum LA
AD  - Division of Cardiovascular Sciences, St Boniface General Hospital Research 
      Centre, Winnipeg, Manitoba.
FAU - Gupta, M
AU  - Gupta M
FAU - Thomas, T P
AU  - Thomas TP
FAU - Singal, P K
AU  - Singal PK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (Free Radicals)
RN  - 1406-18-4 (Vitamin E)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Arrhythmias, Cardiac/chemically induced/*prevention & control
MH  - Cardiomegaly/etiology/*physiopathology
MH  - Epinephrine/*toxicity
MH  - Free Radicals
MH  - Male
MH  - Myocardial Contraction/drug effects
MH  - Premedication
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Vitamin E/*therapeutic use
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
PST - ppublish
SO  - Can J Cardiol. 1990 Mar;6(2):71-4.