PMID- 21380730
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20211020
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 38
IP  - 8
DP  - 2011 Nov
TI  - Effect of TNF-alpha and IL-1beta genetic variants on the development of myocardial 
      infarction in Turkish population.
PG  - 5453-7
LID - 10.1007/s11033-011-0701-x [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) genetic 
      variants which resulting in TNF-alpha and IL-1 overproduction may increase 
      susceptibility to autoimmune diseases such as atherosclerosis. We have studied 
      the association of TNF-alpha G308A and IL-1beta (+3953) C/T polymorphism with myocardial 
      infarction in Turkish population. 143 patients with myocardial infarction and 213 
      age-matched healthy controls were included in the study. In univariant analysis, 
      the frequencies of IL-1beta, TNF-alpha genotype or allele, and haplotype of C:A and T:A 
      were significantly elevated in patients when compared with those of controls. GA 
      genotype of TNF-alpha, T allele of IL-1beta and A of TNF-alpha allele seem to be risk 
      factors for myocardial infarction. In contrast, CC genotype of IL-1beta and GG 
      genotype of TNF-alpha have protective effect against myocardial infarction. In 
      multivariate logistic regression analysis, TNF-alpha A allele, gender and smoking 
      were associated with myocardial infarction. In conclusion, we can state that 
      TNF-alpha A allele might be associated with myocardial infarction.
FAU - Zeybek, Umit
AU  - Zeybek U
AD  - Institute for Experimental Medicine, Department of Molecular Medicine, Istanbul 
      University, Capa, 34390 Istanbul, Turkey.
FAU - Toptas, Bahar
AU  - Toptas B
FAU - Karaali, Zeynep Ermis
AU  - Karaali ZE
FAU - Kendir, Mehmet
AU  - Kendir M
FAU - Cakmakoglu, Bedia
AU  - Cakmakoglu B
LA  - eng
PT  - Journal Article
DEP - 20110306
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genetics, Population
MH  - Haplotypes/genetics
MH  - Humans
MH  - Interleukin-1beta/*genetics
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Infarction/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Turkey
EDAT- 2011/03/08 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/02/26 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1007/s11033-011-0701-x [doi]
PST - ppublish
SO  - Mol Biol Rep. 2011 Nov;38(8):5453-7. doi: 10.1007/s11033-011-0701-x. Epub 2011 
      Mar 6.