PMID- 21381422
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20181201
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 28
IP  - 11
DP  - 2010 Nov
TI  - [Simultaneous analysis of 4 non-steroidal anti-inflammatory drug residues in 
      mutton muscle using high performance liquid chromatography assisted by 
      ultrasonic-microwave extraction].
PG  - 1056-60
AB  - A method for the simultaneous determination of 4 non-steroidal anti-inflammatory 
      drug (NSAID) residues, including flunixin meglumine, meloxicam, diclofenac sodium 
      and ketoprofen, in mutton muscle was developed using high performance liquid 
      chromatography assisted by ultrasonic-microwave extraction. The NSAIDs were 
      extracted with acidified ethanol and purified by a diatomite column. The 
      subsequent analysis of NSAIDs was achieved on a Hypersil C18 column (250 mm x 4.6 
      mm, 5 microm) with the mobile phase of acetonitrile-0.2% triethylamine (40 : 60, 
      v/v, pH 3.5 adjusted by phosphoric acid) at a flow rate of 0.8 mL/min at 30 
      degrees C. The detection wavelength was set at 255 nm. The 4 NSAIDs were well 
      separated within 20 min. The correlation coefficients for 4 NSAIDs were from 
      0.999 3 to 0.999 8 with the limits of detection (LOD, S/N = 3) of 5-10 microg/kg 
      and the limits of quantification (LOQ, S/N = 10) of 15-30 microg/kg. The 
      recoveries were in the range of 65.3% - 99.6% with the relative standard 
      deviations (RSDs) less than 15%. This method is simple, rapid and highly 
      sensitive, and can meet the requirement for the qualitative and quantitative 
      analysis.
FAU - Kang, Yongfeng
AU  - Kang Y
AD  - College of Food Science and Technology, Shanghai Ocean University, Shanghai 
      201306, China. yfkang@shou.edu.cn
FAU - Zou, Shiwen
AU  - Zou S
FAU - Duan, Wuping
AU  - Duan W
FAU - Li, Yan
AU  - Li Y
FAU - Sun, Tao
AU  - Sun T
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Thiazines)
RN  - 0 (Thiazoles)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 8Y3JK0JW3U (flunixin meglumine)
RN  - V7DXN0M42R (Clonixin)
RN  - VG2QF83CGL (Meloxicam)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*analysis
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Clonixin/analogs & derivatives/analysis
MH  - Diclofenac/analysis
MH  - Drug Residues/*analysis
MH  - Food Contamination/analysis
MH  - Meat/*analysis
MH  - Meloxicam
MH  - Microwaves
MH  - Sheep
MH  - Solid Phase Extraction/*methods
MH  - Thiazines/analysis
MH  - Thiazoles/analysis
MH  - Ultrasonics/methods
EDAT- 2011/03/09 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
PST - ppublish
SO  - Se Pu. 2010 Nov;28(11):1056-60.