PMID- 21382270
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20181201
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan-Mar
TI  - Hormones of hypothalamic-pituitary-thyroid axis are significant regulators of 
      synthesis and secretion of vitamin K-dependent plasma coagulation factors.
PG  - 21-6
AB  - Present data about hormonal regulation of haemostasis are often contradictory and 
      are mostly based on clinical observations. The aim of the current research is to 
      study the effects of the hormones of hypothalamic-pituitary-thyroid (HPT) axis on 
      plasma levels (i.e. on the synthesis and secretion) of vitamin K-dependent 
      coagulation factors in rats. The study was carried out on 65 male Wistar rats, 
      divided into five groups. The animals were injected subcutaneously (s.c.) once 
      daily for three consecutive days as follows: the first group was injected with 
      Thyrotropin releasing hormone (TRH), in a dose of 0.06 mg/kg b.w.; the second 
      group by Thyroid stimulating hormone (TSH), with a dose of 1 MU/kg b.w., the 
      third and the fourth group respectively with Liothyroninum (Triiodothyronin ? T3) 
      and Levothyroxinum (Thyroxin ? T4) with a dose of 0.08 mg/kg b.w. each. The 
      control group rats were injected with saline (the solvent of the hormones), 
      following the same schedule and volume per kg b.w. The necessary quantity of 
      blood was acquired by a cardiac puncture under ether narcosis, and antigen levels 
      of plasma factors II, VII, IX and X (FII:Ag, FVII:Ag, FIX:Ag and FX:Ag) were 
      determined by ELISA kits (Diagnostica Stago, France). TRH, TSH, T3 and T4 
      significantly decreased the plasma antigen levels of FII and FVII (p<0.001). TRH, 
      T3 and TSH reduced significantly FIX:Ag level( p<0.001 for TRH and T3 and p<0.05 
      for TSH) while T4 did not exert significant changes ( p>0.05). FX:Ag level was 
      also significantly reduced by TRH, T3 (p<0.001), TSH and T4 (p<0.01). Plasma 
      levels of vitamin K-dependent coagulation factors Fcapital I, Ukrainiancapital I, Ukrainian:Ag, FVcapital I, Ukrainiancapital I, Ukrainian:Ag, Fcapital I, Ukrainiancapital HA, Cyrillic:Ag and 
      Fcapital HA, Cyrillic:Ag are significantly reduced under the influence of the hormones of 
      hypothalamic-pituitary-thyroid axis which signifies their decreased synthesis and 
      secretion. T4 does not induce substantial changes in FIX:Ag plasma level.
FAU - Negrev, N
AU  - Negrev N
AD  - Department of Physiology and Pathophysiology Medical University, Varna, Bulgaria. 
      zam_rector_ud@mu-varna.bg
FAU - Tashev, R
AU  - Tashev R
FAU - Radev, R
AU  - Radev R
FAU - Anogeianaki, A
AU  - Anogeianaki A
FAU - Ivanova, M
AU  - Ivanova M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (Blood Coagulation Factors)
RN  - 0 (Hormones)
RN  - 12001-79-5 (Vitamin K)
SB  - IM
MH  - Animals
MH  - Blood Coagulation Factors/*biosynthesis/*metabolism
MH  - Hormones/metabolism/pharmacology
MH  - Hypothalamo-Hypophyseal System/*metabolism
MH  - Male
MH  - Protein Biosynthesis/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Thyroid Gland/*metabolism
MH  - Vitamin K/*metabolism
EDAT- 2011/03/09 06:00
MHDA- 2011/05/05 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 4 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2011 Jan-Mar;25(1):21-6.