PMID- 21382440
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20131121
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 494
IP  - 2
DP  - 2011 Apr 25
TI  - Methionine diet-induced hyperhomocysteinemia accelerates cerebral aneurysm 
      formation in rats.
PG  - 139-44
LID - 10.1016/j.neulet.2011.02.076 [doi]
AB  - BACKGROUND AND PURPOSE: The pathophysiology of cerebral aneurysms (CA) is linked 
      to chronic inflammation. Endothelial damage is one of the first changes in CA 
      walls resulted from inflammation. It has been shown that increase in plasma 
      homocysteine (Hcy) impairs vascular endothelium and correlates with the 
      development of atherosclerosis. However, the effect of hyperhomocysteinemia 
      (HHcy) on the formation of cerebral aneurysm remains unknown. METHODS: Male 
      Sprague-Dawley rats examined for developing cerebral aneurysms after surgical 
      induction in the presence and absence of hypercysteinemia induced by a high 
      L-methionine diet (1 g/kg/d). Aneurysms developed at the anterior 
      cerebral-olfactory artery bifurcation were classified as 4 stages from no 
      abnormality to saccular aneurysm. Plasma homocysteine levels and expression of 
      vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase 
      (eNOS), inducible nitric oxide synthase (iNOS), matrix metalloproteinase-2 
      (MMP-2), and MMP-9 in aneurysmal walls was examined and correlated with CA 
      formation 3 months after surgery. RESULTS: Methionine diet significantly 
      increased plasma homocysteine levels, accelerates CA formation after ligation of 
      the left common carotid artery. Expression of VEGF, iNOS, MMP-2, and MMP-9 in 
      aneurysmal walls was also increased by methionine treatment. CONCLUSION: 
      Hyperhomocysteinemia accelerates cerebral aneurysm formation, potentially through 
      differential effects on expression of molecules critical for vascular wall 
      modeling in a rat model.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Xu, Yong
AU  - Xu Y
AD  - Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 
      Neurological Institute, Key Laboratory of Post-trauma Neuro-repair and 
      Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052 PR 
      China.
FAU - Tian, Ye
AU  - Tian Y
FAU - Wei, Hui-Jie
AU  - Wei HJ
FAU - Dong, Jing-Fei
AU  - Dong JF
FAU - Zhang, Jian-Ning
AU  - Zhang JN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110304
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - AE28F7PNPL (Methionine)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Diet/*adverse effects
MH  - Endothelium, Vascular/metabolism/pathology
MH  - Hyperhomocysteinemia/chemically induced/*complications
MH  - Inflammation/metabolism
MH  - Intracranial Aneurysm/*etiology/metabolism/pathology
MH  - Male
MH  - Matrix Metalloproteinase 2/biosynthesis
MH  - Matrix Metalloproteinase 9/biosynthesis
MH  - Methionine/*adverse effects
MH  - Nitric Oxide Synthase Type II/biosynthesis
MH  - Nitric Oxide Synthase Type III/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vascular Endothelial Growth Factor A/biosynthesis
EDAT- 2011/03/09 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/09 06:00
PHST- 2010/12/27 00:00 [received]
PHST- 2011/02/05 00:00 [revised]
PHST- 2011/02/27 00:00 [accepted]
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S0304-3940(11)00279-5 [pii]
AID - 10.1016/j.neulet.2011.02.076 [doi]
PST - ppublish
SO  - Neurosci Lett. 2011 Apr 25;494(2):139-44. doi: 10.1016/j.neulet.2011.02.076. Epub 
      2011 Mar 4.