PMID- 21383055
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20211020
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 208
IP  - 3
DP  - 2011 Mar 14
TI  - Herpesvirus telomeric repeats facilitate genomic integration into host telomeres 
      and mobilization of viral DNA during reactivation.
PG  - 605-15
LID - 10.1084/jem.20101402 [doi]
AB  - Some herpesviruses, particularly lymphotropic viruses such as Marek's disease 
      virus (MDV) and human herpesvirus 6 (HHV-6), integrate their DNA into host 
      chromosomes. MDV and HHV-6, among other herpesviruses, harbor telomeric repeats 
      (TMRs) identical to host telomeres at either end of their linear genomes. Using 
      MDV as a natural virus-host model, we show that herpesvirus TMRs facilitate viral 
      genome integration into host telomeres and that integration is important for 
      establishment of latency and lymphoma formation. Integration into host telomeres 
      also aids in reactivation from the quiescent state of infection. Our results and 
      the presence of TMRs in many herpesviruses suggest that integration mediated by 
      viral TMRs is a conserved mechanism, which ensures faithful virus genome 
      maintenance in host cells during cell division and allows efficient mobilization 
      of dormant viral genomes. This finding is of particular importance as 
      reactivation is critical for virus spread between susceptible individuals and is 
      necessary for continued herpesvirus evolution and survival.
FAU - Kaufer, Benedikt B
AU  - Kaufer BB
AD  - Department of Microbiology and Immunology, College of Veterinary Medicine, 
      Cornell University, Ithaca, NY 14853, USA.
FAU - Jarosinski, Keith W
AU  - Jarosinski KW
FAU - Osterrieder, Nikolaus
AU  - Osterrieder N
LA  - eng
GR  - R01 CA127238/CA/NCI NIH HHS/United States
GR  - 5R01CA127238/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110307
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Chickens/genetics/virology
MH  - DNA, Viral/*genetics/physiology
MH  - Herpesviridae/genetics/*physiology
MH  - Herpesvirus 2, Gallid/genetics/physiology
MH  - Marek Disease/genetics/virology
MH  - Mutation/genetics/physiology
MH  - Repetitive Sequences, Nucleic Acid/*genetics/physiology
MH  - Telomere/*genetics/physiology
MH  - Virus Activation/*genetics/physiology
MH  - Virus Integration/*genetics/physiology
PMC - PMC3058580
EDAT- 2011/03/09 06:00
MHDA- 2011/05/25 06:00
PMCR- 2011/09/14
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
PHST- 2011/09/14 00:00 [pmc-release]
AID - jem.20101402 [pii]
AID - 20101402 [pii]
AID - 10.1084/jem.20101402 [doi]
PST - ppublish
SO  - J Exp Med. 2011 Mar 14;208(3):605-15. doi: 10.1084/jem.20101402. Epub 2011 Mar 7.