PMID- 21383234
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20220410
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 21
IP  - 10
DP  - 2011 Oct
TI  - Relationships between beta-amyloid and functional connectivity in different 
      components of the default mode network in aging.
PG  - 2399-407
LID - 10.1093/cercor/bhr025 [doi]
AB  - Although beta-amyloid (Abeta) deposition is a characteristic feature of Alzheimer's 
      disease (AD), this pathology is commonly found in elderly normal controls (NC). 
      The pattern of Abeta deposition as detected with Pittsburgh compound-B positron 
      emission tomography (PIB-PET) imaging shows substantial spatial overlap with the 
      default mode network (DMN), a group of brain regions that typically deactivates 
      during externally driven cognitive tasks. In this study, we show that DMN 
      functional connectivity (FC) during rest is altered with increasing levels of PIB 
      uptake in NC. Specifically, FC decreases were identified in regions implicated in 
      episodic memory (EM) processing (posteromedial cortex, ventral medial prefrontal 
      cortex, and angular gyrus), whereas connectivity increases were detected in 
      dorsal and anterior medial prefrontal and lateral temporal cortices. This pattern 
      of decreases is consistent with previous studies that suggest heightened 
      vulnerability of EM-related brain regions in AD, whereas the observed increases 
      in FC may reflect a compensatory response.
FAU - Mormino, Elizabeth C
AU  - Mormino EC
AD  - Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, 
      CA 94720, USA. bmormino@berkeley.edu
FAU - Smiljic, Andre
AU  - Smiljic A
FAU - Hayenga, Amynta O
AU  - Hayenga AO
FAU - Onami, Susan H
AU  - Onami SH
FAU - Greicius, Michael D
AU  - Greicius MD
FAU - Rabinovici, Gil D
AU  - Rabinovici GD
FAU - Janabi, Mustafa
AU  - Janabi M
FAU - Baker, Suzanne L
AU  - Baker SL
FAU - Yen, Irene V
AU  - Yen IV
FAU - Madison, Cindee M
AU  - Madison CM
FAU - Miller, Bruce L
AU  - Miller BL
FAU - Jagust, William J
AU  - Jagust WJ
LA  - eng
GR  - R01 AG034570/AG/NIA NIH HHS/United States
GR  - AG032814/AG/NIA NIH HHS/United States
GR  - P01 AG019724/AG/NIA NIH HHS/United States
GR  - K23 AG031861/AG/NIA NIH HHS/United States
GR  - AG027859/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110307
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/pathology/*physiology
MH  - Amyloid beta-Peptides/antagonists & inhibitors/biosynthesis/*physiology
MH  - Brain Mapping/methods
MH  - Cerebral Cortex/diagnostic imaging/pathology/physiology
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory, Episodic
MH  - Nerve Net/diagnostic imaging/*metabolism/*physiopathology
MH  - Positron-Emission Tomography/methods
MH  - Young Adult
PMC - PMC3169663
EDAT- 2011/03/09 06:00
MHDA- 2012/06/14 06:00
PMCR- 2012/10/01
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
PHST- 2012/10/01 00:00 [pmc-release]
AID - bhr025 [pii]
AID - 10.1093/cercor/bhr025 [doi]
PST - ppublish
SO  - Cereb Cortex. 2011 Oct;21(10):2399-407. doi: 10.1093/cercor/bhr025. Epub 2011 Mar 
      7.