PMID- 21385858
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20221207
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 26
IP  - 12
DP  - 2011 Dec
TI  - Polymorphism of proinflammatory cytokine genes and albuminuria in the Japanese 
      general population: the Takahata study.
PG  - 3902-7
LID - 10.1093/ndt/gfr105 [doi]
AB  - BACKGROUND: A cluster of proinflammatory cytokines plays an important role in the 
      development of various renal diseases, and the expression of these cytokines is 
      genetically modified. To examine the association between polymorphisms of 
      proinflammatory cytokine genes and albuminuria, a cross-sectional study was 
      conducted in the general population. METHODS: Single nucleotide polymorphisms 
      (SNPs) in six proinflammatory cytokine genes, including interleukin (IL)-1beta, 
      IL-6, IL-8, tumor necrosis factor (TNF)-alpha, CC chemokine ligand 1 (CCL1) and 
      monocyte chemoattractant protein-1 (MCP-1), were genotyped in 2927 Japanese 
      subjects. Urine albumin-creatinine ratio (UACR) was measured in morning spot 
      urine samples. RESULTS: Albuminuria (UACR >/= 30 mg/g) was significantly associated 
      with the A/A + A/G genotype at rs2069852 in the IL-6 gene (P = 0.01) and the A/A 
      genotype at rs228269 in the CCL1 gene (P = 0.002). Multivariate analysis with 
      adjustment for traditional risk factors showed that these genotypes independently 
      predicted albuminuria [odds ratio (OR) 1.782, 95% confidence interval (CI) 
      1.171-2.712, P = 0.007 for the A/A + A/G genotype at rs2069852 in IL-6, and OR 
      1.432, 95% CI 1.128-1.770, P = 0.003 for the A/A genotype at rs228269 in CCL1]. 
      The prevalence of albuminuria and the UACR were increased along with the increase 
      of risk genotypes. CONCLUSIONS: This study revealed that SNPs in the IL-6 and 
      CCL1 genes were associated with albuminuria, and the combination of these 
      genotypes had an additive effect on the prevalence and severity of albuminuria. 
      This indicates that genetic factors influencing inflammatory responses may affect 
      the development of renal injury in the Japanese general population.
FAU - Mashima, Yusuke
AU  - Mashima Y
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, Yamagata, Japan.
FAU - Konta, Tsuneo
AU  - Konta T
FAU - Kudo, Kosuke
AU  - Kudo K
FAU - Suzuki, Kazuko
AU  - Suzuki K
FAU - Ikeda, Ami
AU  - Ikeda A
FAU - Ichikawa, Kazunobu
AU  - Ichikawa K
FAU - Shibata, Yoko
AU  - Shibata Y
FAU - Watanabe, Tetsu
AU  - Watanabe T
FAU - Tamiya, Gen
AU  - Tamiya G
FAU - Kato, Takeo
AU  - Kato T
FAU - Kawata, Sumio
AU  - Kawata S
FAU - Kubota, Isao
AU  - Kubota I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110308
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Albuminuria/*genetics
MH  - Asian People/genetics
MH  - Cross-Sectional Studies
MH  - Cytokines/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2011/03/10 06:00
MHDA- 2012/09/14 06:00
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - gfr105 [pii]
AID - 10.1093/ndt/gfr105 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2011 Dec;26(12):3902-7. doi: 10.1093/ndt/gfr105. Epub 
      2011 Mar 8.