PMID- 21385894
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20220317
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 64
IP  - 5
DP  - 2011 May
TI  - Granulomatous mastitis: the histological differentials.
PG  - 405-11
LID - 10.1136/jcp.2011.089565 [doi]
AB  - BACKGROUND: The management of granulomatous mastitis depends on the causative 
      factor, and accurate diagnosis in distinguishing between idiopathic granulomatous 
      mastitis (IGM) and tuberculous mastitis (TBM) is indispensable. This is 
      particularly problematic in the cases of granulomatous mastitis in which the 
      microbiological studies are negative. In this study, in a large cohort, the 
      histological features for IGM and TBM were compared. METHODS: The histopathology 
      files from the two participating hospitals were searched for cases of 
      granulomatous inflammation of the breast over an 8-year period. The parameters 
      assessed included age of patient, lesional size, systemic and local symptoms, and 
      histological findings of inflammatory cells, granulomas, necrosis, multinucleated 
      giant cells, fibrosis and calcifications. RESULTS: 29 cases of IGM and 33 cases 
      of TBM were included in this study. A significant difference was seen between the 
      two groups with regard to patient age (t=2.52, p<0.05) and lesional size 
      (t=-5.56, p<0.01). TBM occurred in a significantly younger population, and 
      demonstrated larger lesional sizes than IGM. There was no difference between the 
      number of cases showing mass, local and systemic symptoms. Comparing the 
      different histological features, the TBM group showed significantly more 
      fibrosis, eosinophils and necrosis, whereas the IGM group showed significantly 
      more plasma cells. Taking all the cases together as one group to evaluate the 
      relationship between the histological parameters, there was significant positive 
      correlation between eosinophils and fibrosis (r(s)=0.39, p<0.01), and negative 
      correlation between vague and well-formed granulomas (r(s)=-0.38, p<0.01). 
      CONCLUSION: TBM was more likely to occur in younger patients, with a larger 
      clinical mass at presentation. Histologically, TBM tends to show more eosinophils 
      and necrosis, and IGM is associated with more plasma cells. The characteristics 
      of the granulomas and giant cells were not distinguishing features.
FAU - Lacambra, Maribel
AU  - Lacambra M
AD  - Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The 
      Chinese University of Hong Kong, Hong Kong, China.
FAU - Thai, Tu Anh
AU  - Thai TA
FAU - Lam, Christopher C F
AU  - Lam CC
FAU - Yu, Alex M C
AU  - Yu AM
FAU - Pham, Huong Thien
AU  - Pham HT
FAU - Tran, Phuong Viet The
AU  - Tran PV
FAU - Law, Bonita K B
AU  - Law BK
FAU - Van Nguyen, Thanh
AU  - Van Nguyen T
FAU - Pham, Dung Xuan
AU  - Pham DX
FAU - Tse, Gary M
AU  - Tse GM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110308
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Cohort Studies
MH  - Diagnosis, Differential
MH  - Eosinophils
MH  - Female
MH  - Fibrosis/pathology
MH  - Granulomatous Mastitis/*diagnosis
MH  - Humans
MH  - Mastitis/*diagnosis/etiology/microbiology
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Tuberculosis/complications/*diagnosis
MH  - Young Adult
EDAT- 2011/03/10 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jcp.2011.089565 [pii]
AID - 10.1136/jcp.2011.089565 [doi]
PST - ppublish
SO  - J Clin Pathol. 2011 May;64(5):405-11. doi: 10.1136/jcp.2011.089565. Epub 2011 Mar 
      8.