PMID- 21387371
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20220321
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 69
IP  - 2
DP  - 2011 Feb
TI  - Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular 
      disease.
PG  - 257-68
LID - 10.1002/ana.22317 [doi]
AB  - OBJECTIVE: Cerebrovascular disease is 1 of the possible mechanisms of the 
      previously reported relationship between Mediterranean-type diet (MeDi) and 
      Alzheimer's disease (AD). We sought to investigate the association between MeDi 
      and MRI infarcts. METHODS: High-resolution structural MRI was collected on 707 
      elderly 65 years or older community residents of New York with available dietary 
      assessments administered an average of 5.8 years (3.22 standard deviations [SDs]) 
      before the MRI. Participants were divided into 3 groups of adherence to MeDi 
      (low, middle, and high tertiles). We examined the association of increasing 
      adherence to MeDi with presence of infarcts on MRI. Models were run without 
      adjustment, adjusted for basic demographic and clinical factors, and adjusted for 
      vascular risk factors. RESULTS: A total of 222 participants had at least 1 
      infarct. In the unadjusted model, compared to the low adherence group, those in 
      the moderate MeDi adherence group had a 22% reduced odds of having an infarct 
      (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.55-1.14), while 
      participants in the highest MeDi adherence group had a 36% reduced odds (OR, 
      0.64; 95% CI, 0.42-0.97; p for trend = 0.04). In adjusted models, the association 
      between MeDi adherence and MRI infarcts remained essentially unchanged. The 
      association of high MeDi adherence with infarcts was comparable to that of 
      hypertension (40% reduced probability), did not vary by infarct size or after 
      excluding patients with dementia (n = 46) or clinical strokes (n = 86). There was 
      no association between MeDi and white matter hyperintensities. INTERPRETATION: 
      Higher adherence to the MeDi is associated with reduced cerebrovascular disease 
      burden.
CI  - Copyright (c) 2011 American Neurological Association.
FAU - Scarmeas, Nikolaos
AU  - Scarmeas N
AD  - Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 
      University of California at Davis, Sacramento, USA. ns257@columbia.edu
FAU - Luchsinger, Jose A
AU  - Luchsinger JA
FAU - Stern, Yaakov
AU  - Stern Y
FAU - Gu, Yian
AU  - Gu Y
FAU - He, Jing
AU  - He J
FAU - DeCarli, Charlie
AU  - DeCarli C
FAU - Brown, Truman
AU  - Brown T
FAU - Brickman, Adam M
AU  - Brickman AM
LA  - eng
GR  - P01-AG07232/AG/NIA NIH HHS/United States
GR  - K23 AG029949-01/AG/NIA NIH HHS/United States
GR  - R01 AG037212/AG/NIA NIH HHS/United States
GR  - R01 AG028506/AG/NIA NIH HHS/United States
GR  - P30 AG010129/AG/NIA NIH HHS/United States
GR  - R01 AG037212-01/AG/NIA NIH HHS/United States
GR  - K23 AG029949/AG/NIA NIH HHS/United States
GR  - AG028506/AG/NIA NIH HHS/United States
GR  - AG029949/AG/NIA NIH HHS/United States
GR  - R01 AG028506-01A2/AG/NIA NIH HHS/United States
GR  - R01 AG034189/AG/NIA NIH HHS/United States
GR  - P01 AG007232-11A1/AG/NIA NIH HHS/United States
GR  - P01 AG007232/AG/NIA NIH HHS/United States
GR  - R01 AG034189-01A1/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
SB  - IM
CIN - Ann Neurol. 2011 Feb;69(2):226-8. PMID: 21387364
CIN - Ann Neurol. 2011 Dec;70(6):1006; author reply 1006-7. PMID: 22190373
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*pathology
MH  - Analysis of Variance
MH  - Brain/*pathology/physiopathology
MH  - Brain Mapping
MH  - Cerebrovascular Disorders/*etiology/*pathology/physiopathology
MH  - *Diet, Mediterranean
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Motor Activity/physiology
MH  - Neurologic Examination
MH  - Neuropsychological Tests
MH  - New York
MH  - Risk Factors
PMC - PMC3066080
MID - NIHMS279902
COIS- Potential Conflicts of Interest C.D. has grant(s) pending from the NIH. J.H. has 
      received grant(s) from the NIH. J.A.L. has received grant(s) and has grant(s) 
      pending from the NIH. N.S. has received grant(s) from the NIH and has grant(s) 
      pending from the NIH and the Alzheimer's Association. All other authors have 
      nothing to report.
EDAT- 2011/03/10 06:00
MHDA- 2011/05/12 06:00
PMCR- 2012/02/01
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
PHST- 2012/02/01 00:00 [pmc-release]
AID - 10.1002/ana.22317 [doi]
PST - ppublish
SO  - Ann Neurol. 2011 Feb;69(2):257-68. doi: 10.1002/ana.22317.