PMID- 21387385
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20220408
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 69
IP  - 2
DP  - 2011 Feb
TI  - Autoantibodies to low-density lipoprotein receptor-related protein 4 in 
      myasthenia gravis.
PG  - 418-22
LID - 10.1002/ana.22312 [doi]
AB  - Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction, 
      where acetylcholine receptor (AChR), muscle-specific kinase (MuSK), and 
      low-density lipoprotein (LDL) receptor-related protein 4 (Lrp4) are essential. 
      About 80% and 0% to 10% of patients with generalized MG have autoantibodies to 
      AChR and MuSK, respectively, but pathogenic factors are elusive in others. Here 
      we show that a proportion of AChR antibody-negative patients have autoantibodies 
      to Lrp4. These antibodies inhibit binding of Lrp4 to its ligand and predominantly 
      belong to the immunoglobulin G1 (IgG1) subclass, a complement activator. These 
      findings together indicate the involvement of Lrp4 antibodies in the pathogenesis 
      of AChR antibody-negative MG.
CI  - Copyright (c) 2011 American Neurological Association.
FAU - Higuchi, Osamu
AU  - Higuchi O
AD  - Division of Genetics, Department of Cancer Biology, the Institute of Medical 
      Science, the University of Tokyo, Japan.
FAU - Hamuro, Johko
AU  - Hamuro J
FAU - Motomura, Masakatsu
AU  - Motomura M
FAU - Yamanashi, Yuji
AU  - Yamanashi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (LDL-Receptor Related Proteins)
RN  - 0 (Receptors, Cholinergic)
SB  - IM
MH  - Autoantibodies/*immunology
MH  - Humans
MH  - Immunoglobulin G/immunology
MH  - LDL-Receptor Related Proteins/*immunology
MH  - Myasthenia Gravis/*immunology
MH  - Radioimmunoprecipitation Assay
MH  - Receptors, Cholinergic/immunology
EDAT- 2011/03/10 06:00
MHDA- 2011/05/12 06:00
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - 10.1002/ana.22312 [doi]
PST - ppublish
SO  - Ann Neurol. 2011 Feb;69(2):418-22. doi: 10.1002/ana.22312.