PMID- 21388339
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20220409
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 49
IP  - 3
DP  - 2011 Mar
TI  - Homocysteine: a biomarker in neurodegenerative diseases.
PG  - 435-41
LID - 10.1515/CCLM.2011.084 [doi]
AB  - Diseases of the central nervous system are found in patients with severe 
      hyperhomocysteinemia (HHcy). Epidemiological studies show a positive, 
      dose-dependent relationship between mild-to-moderate increases in plasma total 
      homocysteine concentrations (Hcy) and the risk of neurodegenerative diseases, 
      such as Alzheimer's disease, vascular dementia, cognitive impairment or stroke. 
      HHcy is a surrogate marker for B vitamin deficiency (folate, B12, B6) and a 
      neurotoxic agent. The concept of improving the patient's clinical outcome by 
      lowering of Hcy with B vitamins seems to be attractive. Recent B vitamin 
      supplementation trials demonstrated a slowing of brain atrophy and improvement in 
      some domains of cognitive function. Meta-analysis of secondary prevention trials 
      showed that B vitamins supplementation caused a decrease in plasma Hcy and a 
      trend for lowering the risk of stroke. HHcy is common in elderly people. 
      Therefore, it seems prudent to identify B vitamin deficient subjects and to 
      ensure sufficient vitamin intake. Therefore, recent evidence supports the role of 
      Hcy as a potential biomarker in age-related neurodegenerative diseases.
FAU - Herrmann, Wolfgang
AU  - Herrmann W
AD  - Department of Clinical Chemistry, Medical School, Saarland University, Homburg, 
      Germany. kchwher@uks.eu
FAU - Obeid, Rima
AU  - Obeid R
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Biomarkers/blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Neurodegenerative Diseases/*blood
MH  - Vitamin B 12 Deficiency/blood
EDAT- 2011/03/11 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - 10.1515/CCLM.2011.084 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2011 Mar;49(3):435-41. doi: 10.1515/CCLM.2011.084.