PMID- 21388358
OWN - NLM
STAT- MEDLINE
DCOM- 20110627
LR  - 20110310
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 77
IP  - 4
DP  - 2011 Apr
TI  - No extreme genetic risk for type 1 diabetes among DR3/4-DQ8 siblings sharing both 
      extended HLA haplotypes with their diabetic proband.
PG  - 338-40
LID - 10.1111/j.1399-0039.2011.01636.x [doi]
AB  - An extreme genetic risk for type 1 diabetes (T1D) was reported for DR3/4-DQ8 
      siblings sharing both extended human leukocyte antigen (HLA) haplotypes 
      identical-by-descent (IBD) with their diabetic proband. We attempted to replicate 
      this finding in our prospective Dutch T1D cohort and in families from the Type 1 
      Diabetes Genetics Consortium (T1DGC). Only 2 of the 14 Dutch siblings, sharing 
      both DR3-DQ2/DR4-DQ8 haplotypes IBD with their diabetic proband, developed T1D in 
      a 12-year follow-up period. No differential sharing of HLA haplotypes or 
      significant transmission distortion in parents homozygous for HLA risk alleles 
      was found in T1DGC material. Therefore, we could not confirm the reported extreme 
      risk for T1D, suggesting that the risk conferred by other HLA complex loci is 
      moderate.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Eerligh, P
AU  - Eerligh P
AD  - Department of Immunohaematology & Blood Transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands.
FAU - Koeleman, B P C
AU  - Koeleman BP
FAU - Lie, B A
AU  - Lie BA
FAU - Roep, B O
AU  - Roep BO
FAU - Thorsby, E
AU  - Thorsby E
LA  - eng
GR  - U01 DK062418/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Adolescent
MH  - *Alleles
MH  - Child
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens
MH  - HLA-DR3 Antigen/*genetics
MH  - HLA-DR4 Antigen/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Netherlands
MH  - Risk Factors
MH  - *Siblings
EDAT- 2011/03/11 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01636.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Apr;77(4):338-40. doi: 10.1111/j.1399-0039.2011.01636.x.