PMID- 21389094
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20211020
IS  - 1521-0103 (Electronic)
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 337
IP  - 3
DP  - 2011 Jun
TI  - Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to 
      but not self-administration of amphetamine.
PG  - 724-33
LID - 10.1124/jpet.111.180208 [doi]
AB  - Previous exposure to amphetamine leads to enhanced locomotor and nucleus 
      accumbens (NAcc) dopamine (DA) responding to the drug as well as enhanced 
      amphetamine self-administration. Here, we investigated the effects of exposure to 
      Delta(9)-tetrahydrocannibinol (Delta(9)-THC) on behavioral and biochemical responding to 
      amphetamine. Rats in different groups received five exposure injections of 
      vehicle or one of five doses of Delta(9)-THC (0.4, 0.75, 1.5, 3.0, and 6.0 mg/kg 
      i.p.) and were tested 2 days and 2 weeks later. Exposure to all but the lowest 
      and highest doses of Delta(9)-THC enhanced the locomotor response to amphetamine 
      (0.75 mg/kg i.p.), but all failed to enhance NAcc DA overflow in response to the 
      drug. Moreover, exposure to 3.0 mg/kg i.p. Delta(9)-THC increased forskolin-evoked 
      adenylyl cyclase activity in the NAcc and rats' locomotor response to the direct 
      DA receptor agonist apomorphine (1.0 mg/kg s.c.), suggesting that Delta(9)-THC 
      sensitized locomotor responding to amphetamine by up-regulating postsynaptic DA 
      receptor signaling in the NAcc. Finally, amphetamine self-administration (200 
      mug/kg/infusion i.v.) was enhanced in amphetamine (5 x 1.5 mg/kg i.p.)-exposed 
      rats, but not in rats exposed to Delta(9)-THC (5 x 3.0 mg/kg i.p.). Previous exposure 
      to this dose of Delta(9)-THC modestly increased apomorphine SA (0.5 mg/kg/infusion 
      i.v.). Thus, unlike amphetamine exposure, exposure to Delta(9)-THC does not enhance 
      the subsequent NAcc DA response to amphetamine or promote amphetamine 
      self-administration. Although Delta(9)-THC leads to alterations in postsynaptic DA 
      receptor signaling in the NAcc and these can affect the generation of locomotion, 
      these neuroadaptations do not seem to be linked to the expression of enhanced 
      amphetamine self-administration.
FAU - Cortright, James J
AU  - Cortright JJ
AD  - Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 
      South Maryland Avenue, Chicago, IL 60637, USA.
FAU - Lorrain, Daniel S
AU  - Lorrain DS
FAU - Beeler, Jeff A
AU  - Beeler JA
FAU - Tang, Wei-Jen
AU  - Tang WJ
FAU - Vezina, Paul
AU  - Vezina P
LA  - eng
GR  - R01 DA009397/DA/NIDA NIH HHS/United States
GR  - T32 DA007255/DA/NIDA NIH HHS/United States
GR  - R01-DA09397/DA/NIDA NIH HHS/United States
GR  - T32-DA07255/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110309
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Psychotropic Drugs)
RN  - 7J8897W37S (Dronabinol)
RN  - CK833KGX7E (Amphetamine)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
RN  - N21FAR7B4S (Apomorphine)
SB  - IM
MH  - Adenylyl Cyclases/metabolism
MH  - Amphetamine/*administration & dosage/pharmacology
MH  - Animals
MH  - Apomorphine/administration & dosage/pharmacology
MH  - Central Nervous System Stimulants/*administration & dosage/pharmacology
MH  - Dopamine Agonists/administration & dosage/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Dronabinol/*pharmacology
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Nucleus Accumbens/drug effects
MH  - Psychotropic Drugs/metabolism/*pharmacology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Rats, Sprague-Dawley
MH  - Self Administration
PMC - PMC3101004
EDAT- 2011/03/11 06:00
MHDA- 2011/07/20 06:00
PMCR- 2012/06/01
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - jpet.111.180208 [pii]
AID - 3688621 [pii]
AID - 10.1124/jpet.111.180208 [doi]
PST - ppublish
SO  - J Pharmacol Exp Ther. 2011 Jun;337(3):724-33. doi: 10.1124/jpet.111.180208. Epub 
      2011 Mar 9.