PMID- 21392607
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110311
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Linking)
VI  - 161
IP  - 3
DP  - 2011 Mar
TI  - Cardiovascular abnormalities in adults with osteogenesis imperfecta.
PG  - 523-9
LID - 10.1016/j.ahj.2010.11.006 [doi]
AB  - BACKGROUND: The aim of this study was to investigate cardiac abnormalities in 
      adults with osteogenesis imperfecta (OI). METHODS: The clinical and 
      echocardiographic survey included 99 adults with OI divided into 3 clinical 
      types-I, III, and IV-and 52 controls. Left ventricular end-diastolic dimensions 
      (LVIDds), mass, and 4 aortic diameters were measured by standard echocardiography 
      and indexed for body surface area. RESULTS: Hypertension was registered in 37 
      individuals (37.4%). The OI group had significantly lower body surface area than 
      the control individuals, 1.7 +/- 0.3 versus 1.9 +/- 0.2 m(2) (P < .05). The LVIDd and 
      LV mass were significantly larger in the OI group when compared with the 
      controls, 2.98 +/- .64 versus 2.59 +/- .26 cm/m(2) (P < .05) and 97.3 +/- 30.1 versus 
      73.3 +/- 18.0 g/m(2) (P < .05), respectively. Type III OI showed significantly 
      enlarged LVIDd as compared with types I and IV OI, 4.33 +/- 1.10 versus 2.83 +/- .33 
      (P < .05) versus 2.85 +/- .37 cm/m(2) (P < .05), respectively. All aortic diameters 
      were significantly larger in the OI group than in the control group, as they were 
      in type III compared with types I and IV; 10.1% mild aortic regurgitation (AR), 
      10.1% moderate AR, and 7.1% moderate mitral regurgitation were registered in the 
      OI group. CONCLUSIONS: Increased LVIDd, LV mass, mitral regurgitation, and AR 
      were found in adult patients with OI compared with the control group. The changes 
      in LV and dilatation of aorta seemed to be more pronounced in patients with type 
      III compared with types I and IV OI.
CI  - Copyright (c) 2011 Mosby, Inc. All rights reserved.
FAU - Radunovic, Zoran
AU  - Radunovic Z
AD  - Oslo University Hospital-Aker, Norway. zoran.radunovic@medisin.uio.no
FAU - Wekre, Lena L
AU  - Wekre LL
FAU - Diep, Lien M
AU  - Diep LM
FAU - Steine, Kjetil
AU  - Steine K
LA  - eng
PT  - Journal Article
DEP - 20101224
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aorta/pathology
MH  - Aortic Valve Insufficiency/*complications
MH  - Body Surface Area
MH  - Dilatation, Pathologic
MH  - Female
MH  - Heart Ventricles/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/*complications
MH  - Osteogenesis Imperfecta/*complications
MH  - Sinus of Valsalva/pathology
EDAT- 2011/03/12 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/03/12 06:00
PHST- 2010/08/12 00:00 [received]
PHST- 2010/11/07 00:00 [accepted]
PHST- 2011/03/12 06:00 [entrez]
PHST- 2011/03/12 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - S0002-8703(10)01047-1 [pii]
AID - 10.1016/j.ahj.2010.11.006 [doi]
PST - ppublish
SO  - Am Heart J. 2011 Mar;161(3):523-9. doi: 10.1016/j.ahj.2010.11.006. Epub 2010 Dec 
      24.