PMID- 21394187
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20211020
IS  - 1539-4522 (Electronic)
IS  - 0003-6935 (Print)
IS  - 1559-128X (Linking)
VI  - 50
IP  - 8
DP  - 2011 Mar 10
TI  - Full-range k-domain linearization in spectral-domain optical coherence 
      tomography.
PG  - 1158-63
LID - 10.1364/AO.50.001158 [doi]
AB  - A full-bandwidth k-domain linearization method for spectral-domain optical 
      coherence tomography (SD-OCT) is demonstrated. The method uses information of the 
      wavenumber-pixel-position provided by a translating-slit-based wavelength filter. 
      For calibration purposes, the filter is placed either after a broadband source or 
      at the end of the sample path, and the filtered spectrum with a narrowed line 
      width ( approximately 0.5 nm) is incident on a line-scan camera in the detection path. The 
      wavelength-swept spectra are co-registered with the pixel positions according to 
      their central wavelengths, which can be automatically measured with an optical 
      spectrum analyzer. For imaging, the method does not require a filter or a 
      software recalibration algorithm; it simply resamples the OCT signal from the 
      detector array without employing rescaling or interpolation methods. The accuracy 
      of k-linearization is maximized by increasing the k-linearization order, which is 
      known to be a crucial parameter for maintaining a narrow point-spread function 
      (PSF) width at increasing depths. The broadening effect is studied by changing 
      the k-linearization order by undersampling to search for the optimal value. The 
      system provides more position information, surpassing the optimum without 
      compromising the imaging speed. The proposed full-range k-domain linearization 
      method can be applied to SD-OCT systems to simplify their hardware/software, 
      increase their speed, and improve the axial image resolution. The experimentally 
      measured width of PSF in air has an FWHM of 8 mum at the edge of the axial 
      measurement range. At an imaging depth of 2.5 mm, the sensitivity of the 
      full-range calibration case drops less than 10 dB compared with the uncompensated 
      case.
FAU - Jeon, Mansik
AU  - Jeon M
AD  - School of Electrical Engineering and Computer Science, Kyungpook National 
      University, Sankyuk-dong, Buk-gu, Daegu, South Korea.
FAU - Kim, Jeehyun
AU  - Kim J
FAU - Jung, Unsang
AU  - Jung U
FAU - Lee, Changho
AU  - Lee C
FAU - Jung, Woonggyu
AU  - Jung W
FAU - Boppart, Stephen A
AU  - Boppart SA
LA  - eng
GR  - R01 EB012479/EB/NIBIB NIH HHS/United States
GR  - R01 EB012479-01/EB/NIBIB NIH HHS/United States
GR  - R01EB012479/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Appl Opt
JT  - Applied optics
JID - 0247660
SB  - IM
MH  - Algorithms
MH  - Calibration
MH  - Cornea/ultrastructure
MH  - Equipment Design
MH  - Humans
MH  - Image Enhancement/instrumentation
MH  - Retina/ultrastructure
MH  - Sensitivity and Specificity
MH  - Spectrum Analysis/*instrumentation
MH  - *Tomography, Optical Coherence/instrumentation/methods
PMC - PMC3199945
MID - NIHMS314690
EDAT- 2011/03/12 06:00
MHDA- 2011/06/22 06:00
PMCR- 2012/03/10
CRDT- 2011/03/12 06:00
PHST- 2011/03/12 06:00 [entrez]
PHST- 2011/03/12 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
PHST- 2012/03/10 00:00 [pmc-release]
AID - 210611 [pii]
AID - 10.1364/AO.50.001158 [doi]
PST - ppublish
SO  - Appl Opt. 2011 Mar 10;50(8):1158-63. doi: 10.1364/AO.50.001158.