PMID- 21394305
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20211020
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 26
IP  - 3
DP  - 2011 Mar
TI  - Hypoxemia and arrhythmia during daily activities and six-minute walk test in 
      fibrotic interstitial lung diseases.
PG  - 372-8
LID - 10.3346/jkms.2011.26.3.372 [doi]
AB  - We performed 24-hr monitoring of pulse oximetric saturation (SpO(2)) with ECG and 
      six-minute walk test (6MWT) in 19 patients with fibrotic interstitial lung 
      diseases (ILD) to investigate; 1) The frequency and severity of hypoxemia and 
      dysrhythmia during daily activities and 6MWT, 2) safety of 6MWT, and 3) the 
      parameters of 6MWT which can replace 24-hr continuous monitoring of SpO(2) to 
      predict hypoxemia during daily activities. All patients experienced waking hour 
      hypoxemia, and eight of nineteen patients spent > 10% of waking hours in 
      hypoxemic state. Most patients experienced frequent arrhythmia, mostly atrial 
      premature contractions (APCs) and ventricular premature contractions (VPCs). 
      There were significant correlation between the variables of 6MWT and hypoxemia 
      during daily activities. All of the patients who desaturated below 80% before 300 
      meters spent more than 10% of waking hour in hypoxemia (P = 0.018). In contrast 
      to waking hour hypoxemia, SpO(2) did not drop significantly during sleep except 
      in the patients whose daytime resting SpO(2) was already low. In conclusion, 
      patients with fibrotic ILD showed significant period of hypoxemia during daily 
      activities and frequent VPCs and APCs. Six-minute walk test is a useful surrogate 
      marker of waking hour hypoxemia and seems to be safe without continuous 
      monitoring of SpO(2).
FAU - Park, Jeong Hyun
AU  - Park JH
AD  - Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University 
      of Ulsan, College of Medicine, 86 Asanbyeongwon-gil, Seoul, Korea.
FAU - Jegal, Yangjin
AU  - Jegal Y
FAU - Shim, Tae Sun
AU  - Shim TS
FAU - Lim, Chae-Man
AU  - Lim CM
FAU - Lee, Sang Do
AU  - Lee SD
FAU - Koh, Younsuck
AU  - Koh Y
FAU - Kim, Woo Sung
AU  - Kim WS
FAU - Kim, Won Dong
AU  - Kim WD
FAU - du Bois, Roland
AU  - du Bois R
FAU - Do, Kyung-Hyun
AU  - Do KH
FAU - Kim, Dong Soon
AU  - Kim DS
LA  - eng
PT  - Journal Article
DEP - 20110225
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - *Activities of Daily Living
MH  - Aged
MH  - Arrhythmias, Cardiac/*physiopathology
MH  - Dyspnea/physiopathology
MH  - Electrocardiography, Ambulatory
MH  - Exercise Test
MH  - Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Hypoxia/*physiopathology
MH  - Lung Diseases, Interstitial/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Motor Activity/*physiology
MH  - Oximetry
MH  - Respiratory Function Tests
MH  - Sleep
MH  - Walking
PMC - PMC3051084
OTO - NOTNLM
OT  - Anoxia
OT  - Arrhythmias, Cardiac
OT  - Lung Diseases, Interstitial
OT  - Six-Minute Walk Test
EDAT- 2011/03/12 06:00
MHDA- 2011/09/17 06:00
PMCR- 2011/03/01
CRDT- 2011/03/12 06:00
PHST- 2010/09/20 00:00 [received]
PHST- 2011/01/21 00:00 [accepted]
PHST- 2011/03/12 06:00 [entrez]
PHST- 2011/03/12 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - 10.3346/jkms.2011.26.3.372 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2011 Mar;26(3):372-8. doi: 10.3346/jkms.2011.26.3.372. Epub 
      2011 Feb 25.