PMID- 21395176
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20171116
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 24
IP  - 24
DP  - 2010 Dec
TI  - [The expression of DNMT1 in laryngeal squamous cell carcinoma and its clinical 
      significance].
PG  - 1105-7, 1111
AB  - OBJECTIVE: To investigate the expression of DNMT1 in laryngeal squamous cell 
      carcinoma (LSCC) and its relationship with clinicopathological factors. METHOD: 
      Ninety-six cases of LSCC samples were detected by immunohistochemical staining to 
      analyze the expression of DNMT1 protein, while 66 cases of them were detected by 
      real-time PCR. And the relationship between the expression of DNMT1 mRNA and 
      clinicopathologic factors was then analyzed. RESULT: The expression of DNMT1 mRNA 
      in LSCC were up-regulated (P < 0.05). The positive rate of DNMT1 protein 
      expression in LSCC and in peri-cancer tissue were 100% (96/96) and 36% (8/22) 
      respectively, which showed a significant difference (P < 0.05). DNMT1 mRNA 
      expression wasn't correlated with patients' age, gender, T stage and lympha node 
      metastasis, but was associated with smoking habit (P < 0.05, respectively). 
      CONCLUSION: DNMT1 may initiate the oncogenesis of LSCC by increasing expression, 
      and smoking habit may induce the expression of DNMT1 gene.
FAU - Wang, Jin
AU  - Wang J
AD  - Department of Otolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, 110004, China. wangjin068427@hotmail.com
FAU - Li, Jun
AU  - Li J
FAU - Sun, Xin
AU  - Sun X
FAU - Zhang, Mingming
AU  - Zhang M
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferase 1)
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
RN  - EC 2.1.1.37 (DNMT1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - DNA (Cytosine-5-)-Methyltransferase 1
MH  - DNA (Cytosine-5-)-Methyltransferases/genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Smoking
EDAT- 2011/03/15 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Dec;24(24):1105-7, 1111.